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Catalog No. T4721 Cas No. 1094-61-7
Alias β-NM, NMN
β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
Catalog No. T4721 Alias β-NM, NMN Cas No. 1094-61-7
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Q What’s Ki?
A Inhibitory consent (Ki) reflects the strength of inhibitor binding to the target, corresponding to the concentration of free inhibitor when 50% of the target is bound by the inhibitor.
Q What’s Kd?
A Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Q What’s EC50?
A Half maximal effective concentratioin(EC50) refers to the concentration of a compound that achieves 50% of the maximum effect(inhibitory/stimulatory effect),after a specified exposure duration.
Q What’s pIC50?
A pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
Q Does the compound differ in any way when it is in the form of hydrochloride or sulfate ions? What is the difference between the salt form and the free form?
A The molecules in salt and non-salt forms exhibit the same activity, and they have consistent effects in biological experiments. Their activity and usage are identical. The only difference lies in their salt forms, which may result in variations in physical properties such as solubility. It is recommended to choose based on solubility and experimental requirements.
Purity:99.58%
Color:White
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Description β-nicotinamide mononucleotide (NMN) is a natural nucleotide and a key intermediate in the synthesis of coenzyme I (NAD+). β-nicotinamide mononucleotide is involved in a number of biochemical reactions in the human body, which are related to immunity and metabolism.
METHODS: Human corneal epithelial cells HCECs were treated with glucose (25 mM) and β-nicotinamide mononucleotide (5-1000 µM) for 48 h. Cell viability was measured by Trypan blue staining.
RESULTS: The effects of different concentrations of β-nicotinamide mononucleotide on HCEC damage induced by high glucose were analyzed. 125, 250 and 500 µM β-nicotinamide mononucleotide showed significant protective effects. 1
METHODS: Late passaged MSCs LP MSCs were treated with β-nicotinamide mononucleotide (100 µM) for 24 h and mitochondrial morphology was analyzed.
RESULTS: The mitochondrial staining in LP-MSCs was more diffuse and less intense, while the distribution of mitochondria became concentrated after β-nicotinamide mononucleotide treatment. β-nicotinamide mononucleotide treatment could effectively normalize the mitochondrial morphology and improve the function of mitochondria in senescent MSCs. 2
METHODS: To study the effects on aging, β-nicotinamide mononucleotide (100-300 mg/kg) was administered in drinking water to normally aging wild-type C57BL/6N mice. The administration began at 5 months of age and continued for 12 months until the mice were 17 months old.
RESULTS: β-nicotinamide mononucleotide effectively attenuated age-related physiological decline in mice. β-nicotinamide mononucleotide did not have any significant toxic or deleterious effects, inhibited age-related weight gain, enhanced energy metabolism, promoted physical activity, improved insulin sensitivity and lipid levels, and improved insulin resistance. sensitivity and lipid levels, and improved eye function and other pathophysiology. 3
Synonyms β-NM, NMN
Molecular Weight 334.22
Formula C 11 H 15 N 2 O 8 P
Cas No.1094-61-7
Smiles NC(=O)c1ccc n (c1) C@@H 1O C@H (COP(O)( O- )=O) C@@H (O) C@H 1O
Relative Density.no data available
Storage keep away from direct sunlight,store at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information DMSO: Insoluble
H2O: 85.8 mg/mL (256.72 mM), Sonication is recommended.
H2O
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method: For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH 2 O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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