Helen Frankenthaler Foundation

Anti-aging structural peptide

Anti-Aging Peptides | PeptiRank

Peptides with Anti-Aging Effects

Peptides that have shown Anti-Aging effects in research.

Cerebrolysin

Also known as: FPF-1070

A porcine brain-derived neuropeptide mixture containing BDNF, NGF, GDNF, and CNTF fragments. Approved in 50+ countries for stroke, TBI, and dementia.

3.7(7 reviews)

Mod GRF 1-29

Also known as: CJC-1295 No DAC, CJC-1295 without DAC, Modified GRF 1-29

A modified 29-amino-acid GHRH analog without DAC conjugation. Short half-life (30-60 min) produces acute GH pulses that mimic natural secretion patterns.

4.0(24 reviews)

Thymalin

Also known as: Thymic peptide complex, Thymaline

A polypeptide complex derived from calf thymus gland that regulates T-cell maturation, immune surveillance, and cytokine balance. Approved in Russia for immunodeficiency states.

3.8(5 reviews)

SS-31

Also known as: Elamipretide, MTP-131, Bendavia

Synthetic tetrapeptide that concentrates in mitochondria and stabilizes cardiolipin. Restores ATP production and reduces oxidative damage in aged tissue.

3.5(13 reviews)

FOXO4-DRI

Also known as: Proxofim, FOXO4-D-Retro-Inverso

49-amino-acid senolytic peptide that kills senescent cells by disrupting the FOXO4-p53 interaction. Restored fur density and kidney function in aged mice.

3.5(12 reviews)

5-Amino-1MQ

Also known as: 5-Amino-1-methylquinolinium

Small-molecule NNMT inhibitor that raises intracellular NAD+ and suppresses fat cell formation. Reversed diet-induced obesity in mice without reducing food intake.

3.9(7 reviews)

Dihexa

Also known as: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408

Orally active peptide derivative that enhances synaptic connectivity via HGF/c-Met signaling. Reported up to 10 million times more potent than BDNF in certain binding assays.

3.7(9 reviews)

Pinealon

Also known as: EDR peptide, Glu-Asp-Arg

Synthetic tripeptide (Glu-Asp-Arg) from the Khavinson bioregulator family. Studied for neuroprotection, memory, and circadian rhythm regulation.

3.9(10 reviews)

Cortagen

Also known as: AEDP peptide, Ala-Glu-Asp-Pro

Synthetic tetrapeptide (Ala-Glu-Asp-Pro) from the Khavinson family. Modulates gene expression in neural tissue with anti-inflammatory and neuroprotective effects in preclinical work.

3.3(4 reviews)

MOTS-c

Also known as: Mitochondrial ORF of the Twelve S rRNA type-c

16-amino-acid mitochondrial-derived peptide that activates AMPK. Improves insulin sensitivity and exercise capacity in preclinical models.

3.7(23 reviews)

Humanin

Also known as: HN, HNG (S14G-Humanin)

24-amino-acid mitochondrial-derived peptide with cytoprotective activity. Studied for protection against oxidative stress, neurodegeneration, and age-related cell damage.

3.0(1 review)

CJC-1295

Also known as: CJC-1295 DAC, Drug Affinity Complex

A 30-amino-acid GHRH analog with a Drug Affinity Complex (DAC) that binds albumin, extending its half-life to 6-8 days.

4.1(20 reviews)

Sermorelin

Also known as: GRF 1-29, Geref

The first 29 amino acids of GHRH, retaining full receptor activity. FDA-approved (Geref) for pediatric GH deficiency.

3.5(20 reviews)

Tesamorelin

Also known as: Egrifta, TH9507

FDA-approved GHRH analog (Egrifta) for reducing visceral fat in HIV-associated lipodystrophy. Full 44-amino-acid GHRH sequence with an N-terminal stabilizing modification.

3.3(48 reviews)

MK-677

Also known as: Ibutamoren, MK-0677, L-163,191

Oral (non-peptide) ghrelin receptor agonist developed by Merck. Sustains elevated GH and IGF-1 for ~24 hours per dose.

3.2(21 reviews)

BPC-157

Also known as: Body Protection Compound-157, PL 14736, Bepecin

A 15-amino-acid peptide from human gastric juice. Studied for healing tendons, ligaments, muscle, gut lining, and bone in animal models.

4.2(35 reviews)

Epithalon

Also known as: Epitalon, Epithalone, AEDG peptide

A tetrapeptide (AEDG) derived from pineal gland extract Epithalamin. Activates telomerase and regulates melatonin production.

4.0(23 reviews)

GHK-Cu

Also known as: Copper Peptide, GHK-Copper

A copper-binding tripeptide found naturally in blood, saliva, and urine. Plasma levels drop from ~200 ng/mL at age 20 to ~80 ng/mL by age 60.

4.1(50 reviews)

Thymosin Alpha-1

Also known as: Ta1, Thymalfasin, Zadaxin

A 28-amino-acid thymic peptide approved as Zadaxin in 35+ countries for hepatitis B/C and as a vaccine/chemo adjunct.

4.0(8 reviews)

Semax

Also known as: MEHFPGP, Semax 1%

Heptapeptide based on ACTH(4-10) with a Pro-Gly-Pro tail. Approved in Russia and Ukraine for stroke, TIA, and as a nootropic.

3.2(18 reviews)