16. February 2026
Dipeptide-2 is a small but powerful cosmetic active ingredient that is used in particular in eye care products. Due to its ability to improve skin microcirculation and promote lymphatic drainage, it is often used in products designed to reduce dark circles and puffiness around the eyes. In this article, you will learn all about the physicochemical properties, efficacy, advantages, disadvantages, and examples of use of this active ingredient.
Dipeptide-2 is a peptide consisting of two amino acids: tryptophan (W) and valine (V). This small molecular structure allows for good skin penetration and ensures rapid action in cosmetic formulations.
Dipeptide-2 is an effective angiotensin-converting enzyme (ACE) inhibitor that inhibits the conversion of angiotensin I to angiotensin II. This reduces capillary constriction, leading to improved microcirculation. This effect is particularly beneficial for the eye area, as it helps to minimize bags under the eyes and lighten dark circles.
A clinical study involving 36 subjects who applied an emulsion product containing 0.2% dipeptide-2 twice daily showed significant improvements after four weeks:
These results prove that dipeptide-2 achieves visible results even in low concentrations.
Dipeptide-2 offers a variety of advantages, especially for sensitive skin types:
By inhibiting ACE, dipeptide-2 promotes blood circulation and prevents vasoconstriction.
Thanks to its ability to improve lymphatic drainage, dipeptide-2 helps to reduce fluid accumulation under the eyes more quickly.
Dipeptide-2 is skin-friendly, does not cause irritation, and is also suitable for sensitive skin.
Due to its good solubility in water, dipeptide-2 can be easily integrated into emulsions, gels, or serums.
Dipeptide-2 can be combined with other anti-aging and moisturizing agents to further improve skin texture.
