Authored by: Arthur Ghochikyan, M.D.
1114970-34-1
Hexapeptide-33
Synthetic
Hexapeptide-33 is a biologically active peptide with the sequence Ser-Phe-Lys-Leu-Arg-Tyr-NH 2(SFKLRY) that stimulates blood vessel formation, known under the trade name W3 peptide. It was developed by Novacell Technology (NCP901) using peptide library technology.
Hexapeptide-33 targets G-Protein-Coupled-Receptors (GPCR) widely distributed in human body cells. Novel studies showed that a subtype of the GPCR family, the Adhesion G-Protein-Coupled Receptor (aGPCR), is expressed in skin keratinocytes and is involved in epidermal differentiation.
The manufacturer claims a triple beneficial effect starting with "W":
Hexapeptide-33 is used in many anti-aging products, including facial creams, masks, and treatments. The safety assessment of the peptide showed that it is not irritating at the concentrations used in cosmetics and is well tolerated by the skin.
2025-11-05
Author(s): Lee CH, Lee MS, Kim SJ, Je YT, Ryu SH, Lee T
PMID: 18992291
DOI: 10.1016/j.peptides.2008.10.003
Author(s): Kim DH, Lim YY, Kim HM, Kim SY, Kim BJ, Park SG, Lee T, Cho SM
PMID: 24278589
DOI: 10.5487/TR.2012.28.1.051
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