PLP 139-151 peptides are widely used to induce Experimental Autoimmune Encephalomyelitis (EAE), a model for studying multiple sclerosis and other autoimmune disorders. Using MD Bioproducts high-quality PLP 139-151 to trigger EAE, researchers can investigate immune response mechanisms and disease progression and evaluate potential therapeutic interventions. This model is crucial for advancing our understanding and treatment of autoimmune diseases affecting the central nervous system.
SKU: 301008
Size: 15 mg
Purified myelin proteolipid protein (PLP) for PLP-induced EAE models in mouse and rat.
Multiple Sclerosis (MS) is a demyelinating disease of the central nervous system (CNS). The main characteristics of the disease are focal areas of demyelination and inflammation, however the pathogenesis is unclear.
Although no animal model thus far establishes all facets of human MS, Experimental Autoimmune Encephalomyelitis (EAE) represents the model most studied for the disease. Initially brain homogenates were used as antigens for immunization. Today, myelin related proteins or peptides are used in the disease.
