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TN1464
109232-77-1
Camellianin A is a flavonoid series of compounds derived from A. nitida and tea that exhibits anticancer activity, inhibits angiotensin-converting enzyme (ACE) activity, and promotes apoptosis in Hep G2 and MCF-7 cells.Camellianin A prevents CCl4-induced liver injury by exerting anti-oxidative stress, anti-inflammatory, and anti-apoptotic properties.
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Q What’s IC50?
A Half-maximal inhibitory concentration (IC50) refers to the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by half.
Q What’s pIC50?
A pIC50 is the negative log of the IC50 value when converted to molar.That is, pIC50=-log(IC50).
Q Does the compound differ in any way when it is in the form of hydrochloride or sulfate ions? What is the difference between the salt form and the free form?
A The molecules in salt and non-salt forms exhibit the same activity, and they have consistent effects in biological experiments. Their activity and usage are identical. The only difference lies in their salt forms, which may result in variations in physical properties such as solubility. It is recommended to choose based on solubility and experimental requirements.
Q What’s Kd?
A Dissociation consent (Kd) reflects the affinity of a compound for its target. In some cases, it can be equivalent to Ki.
Q What’s Ki?
A Inhibitory consent (Ki) reflects the strength of inhibitor binding to the target, corresponding to the concentration of free inhibitor when 50% of the target is bound by the inhibitor.
Purity:99.37%
Appearance:Solid
Color:White
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Description Camellianin A is a flavonoid series of compounds derived from A. nitida and tea that exhibits anticancer activity, inhibits angiotensin-converting enzyme (ACE) activity, and promotes apoptosis in Hep G2 and MCF-7 cells.Camellianin A prevents CCl4-induced liver injury by exerting anti-oxidative stress, anti-inflammatory, and anti-apoptotic properties. In vitro Camelliasin A inhibits proliferation of human liver cancer Hep G2 cells and human breast cancer MCF-7 cells in a dose-dependent manner, inducing a significant increase in G0/G1 cell cycle arrest.
Molecular Weight 620.56
Formula C 29 H 32 O 15
Cas No.109232-77-1
Smiles O(C1=C2C(OC(=CC2=O)C3=CC=C(O)C=C3)=CC(O)=C1)[C@@H]4O[C@H](COC(C)=O)[C@@H](O[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@H](O)[C@H]4O
Relative Density.1.64g/cm3
Storage store at low temperature,keep away from direct sunlight | store at -20°C | Shipping with blue ice/Shipping at ambient temperature.
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method: For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH 2 O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline, PBS or ddH 2 O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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