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Wang, Haiyan; Deng, Libing; Shan, Yu; Wang, Aizhong; Zhang, Hui; Wang, Yan
March 03, 2026
This study explores the role of protein kinase C beta 2 (PKCβ2) in hypertension-related vascular issues, focusing on mesenteric arteries in spontaneously hypertensive rats (SHR). Researchers found that PKCβ2 expression was elevated in SHR, and S1P significantly increased PKCβ2 phosphorylation, contributing to artery hypercontraction. Sphingosine 1-phosphate (S1P) was shown to activate PKCβ2 through its receptors S1P2 and S1P3, enhancing calcium sensitization and contraction. Inhibiting PKCβ2 reduced norepinephrine and S1P-induced contraction, suggesting that the S1P/PKCβ2 pathway could be a target for treating hypertensive vascular dysfunction. This highlights the potential for new therapeutic strategies in managing hypertension.
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Pizzi, D.; Fazzini, L.; Bassil, D.; Bajaj, P.; Pugliesi, Gm.; Dessalvi, C. Cadeddu
This study reviewed seven randomized controlled trials involving 686 patients to assess if angiotensin-converting enzyme inhibitors (ACEi) can prevent heart damage in those receiving anthracycline-based chemotherapy, commonly used for breast cancer. Half of the patients received ACEi as a preventive measure. Results showed that ACEi helped reduce the decline in heart function, specifically left ventricular ejection fraction (LVEF), especially in patients also treated with trastuzumab. However, ACEi did not significantly affect other heart function measures or troponin levels. Further research with larger sample sizes and longer follow-up is needed to confirm these findings.
Frati, Giacomo; Peruzzi, Mariangela; Giordano, Salvatore; Biondi-Zoccai, Giuseppe
March 02, 2026
Tan, Jie; Gu, Jun
Coronary heart disease (CHD) is a major global health issue, and recent research has focused on angiotensin-like proteins (ANGPTLs) due to their role in lipid metabolism and inflammation. ANGPTLs are glycoproteins that regulate lipid levels by affecting lipoprotein lipase activity, and their dysfunction can lead to dyslipidemia and atherosclerosis. They also contribute to inflammation, worsening CHD. Current therapies targeting ANGPTLs, like monoclonal antibodies and small interfering RNA, are in clinical trials and show promise in safely lowering lipid levels. This study reviews ANGPTLs' role in CHD and highlights the potential of ANGPTL-targeted treatments for prevention and therapy.
Usai, Diana S; Kudryavtseva, Olga; Thomsen, Morten B
February 27, 2026
This study explored how hypertension affects the natural daily cycle of blood pressure in mice, specifically whether it leads to a "non-dipper" phenotype, where the usual nighttime drop in blood pressure is reduced. Researchers induced hypertension in mice using L-NAME and monitored their blood pressure continuously. Initially, most mice showed a normal dipping pattern, but after hypertension was induced, only 42% maintained this pattern. The study also tested three mineralocorticoid receptor antagonists (MRAs) to see if they could restore the dipping pattern. Results showed that these MRAs did not affect the 24-hour blood pressure cycle or restore the dipping phenotype in hypertensive mice.
Weber, Brittany; McCarty, Delilah; Robar, Carey; Fainberg, Udi; Fudim, Marat; Byrne, Katherine; Gluckman, Ty J.
February 25, 2026
