Helen Frankenthaler Foundation

Collagen stimulating decapeptide

Scientific Literature

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Scientific Literature

There exists a wealth of scientific research and papers from across the world relating to the benefits of collagen – and specifically Bioactive Collagen Peptides® – in respect of bone health.

This broad selection of scientific literature supports the rationale for Bioactive Collagen Peptides®, as found in bonebalance™, which start to work in 6 days

This is shown in the 2016 König D, Oesser S. Report on the study “Impact of specific bioactive collagen peptides on the bone mineral density in postmenopausal women”. This key section highlights this point.

Clinically Significant Bone Density Improvements

It is clear that specific Bioactive Collagen Peptides® bring bone density improvements that are clinically significant and compare favourably with prescription drugs.

These are the findings of the Konig 2021 paper itself a follow-up to the Konig 2018 paper which stated the ‘Clinical trial showed a 4.2% higher BMD in the spine and a 7.7% higher BMD in the femoral neck (hip). This compares favourably with prescription treatments.’

After taking specific Bioactive Collagen Peptides® for four years, participants in the trial showed a 9.99% relative improvement in bone mineral density in their spine and 11.91% relative improvement in their hip.

The Konig 2021 paper concluded ‘Although further research is needed, specific Bioactive Collagen Peptides® could offer an innovative therapeutic approach for a long-term osteoporosis treatment with good tolerability without the potential side effects of some forms of drug treatment.’

FORTIBONE®: The Key Ingredient

FORTIBONE® – the one and only ingredient of bonebalance™ – brings bone density improvements that are clinically significant and compare favourably with prescription drugs.

These are the findings of the Konig 2021 paper itself a follow-up to the Konig 2018 paper which stated the ‘Clinical trial showed a 4.2% higher BMD in the spine and a 7.7% higher BMD in the femoral neck (hip). This compares favourably with prescription treatments.’

After taking FORTIBONE for four years, participants in the trial showed a 9.99% relative improvement in bone mineral density in their spine and 11.91% relative improvement in their hip.

The Konig 2021 paper concluded ‘Although further research is needed, specific bioactive collagen peptides (FORTIBONE®) could offer an innovative therapeutic approach for a long-term osteoporosis treatment with good tolerability without the potential side effects of some forms of drug treatment.’

Further evidence in support of the rationale of specific Bioactive Collagen Peptides® as used in bonebalance ™ can be found in these studies.Please if you would like further explanation or clarification.

Reference Studies

  • König D, Oesser S. Report on the study “Impact of specific bioactive collagen peptides (FORTIBONE®) on the bone mineral density in postmenopausal women”. 05.10.2016.
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  • Ohara, H.; Matsumoto, H.; Ito, K.; Iwai, K.; Sato, K. Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources. J. Agric. Food Chem. 2007, 55, 1532–1535.
  • Shimizu, K.; Sato, M.; Zhang, Y.; Kouguchi, T.; Takahata, Y.; Morimatsu, F.; Shimizu, M. The bioavailable octapeptide Gly-Ala-Hyp-Gly-Leu-Hyp-Gly-Pro stimulates nitric oxide synthesis in vascular endothelial cells. J. Agric. Food Chem. 2010, 58, 6960–6965.
  • Oesser, S.; Seifert, J. Stimulation of type II collagen biosynthesis and secretion in bovine chondrocytes cultured with degraded collagen. Cell Tissue Res. 2003, 311, 393–399.
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