Helen Frankenthaler Foundation

Coptisine Extract

Coptisine (Coptisin) | CAS 3486-66-6 | AbMole BioScience

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Coptisine

Cat. No. M4408

All AbMole products are for research use only, cannot be used for human consumption.

Synonym: Coptisin

SizePriceAvailabilityQuantity
20mgUSD 150In stock

Free Delivery on orders over USD 500

Quality Control & Documentation
  • Purity: 99.85%
  • COA
  • MSDS
  • H-NMR
  • HPLC
Biological Activity

Coptisine, an alkaloid isolated from Coptis, is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.

Chemical Information

Molecular Weight 320.32

Formula C19H14NO4+

CAS Number 3486-66-6

Storage Powder -20°C 3 years; 4°C 2 years

In solvent -80°C 6 months; -20°C 1 month

References
  • [1] Yan Zhou, et al. Coptisine Attenuates Diabetes-Associated Endothelial Dysfunction through Inhibition of Endoplasmic Reticulum Stress and Oxidative Stress
  • [2] So Young Kim, et al. Coptisine induces autophagic cell death through down-regulation of PI3K/Akt/mTOR signaling pathway and up-regulation of ROS-mediated mitochondrial dysfunction in hepatocellular carcinoma Hep3B cells
  • [3] Shengmei Sun, et al. Coptisine alleviates ischemia/reperfusion-induced myocardial damage by regulating apoptosis-related proteins
  • [4] Jiasi Wu, et al. Coptisine from Coptis chinensis exerts diverse beneficial properties: A concise review
  • [5] Ya-Li Zhang, et al. Coptisine suppresses proliferation and inhibits metastasis in human pancreatic cancer PANC-1 cells
Related IDO Products
ProductDescription
IDO-IN-2 (NLG-919 Analogue)NLG919 is a potent IDO (indoleamine-(2,3)-dioxygenase) pathway inhibitor with K i/EC50 of 7 nM/75 nM.
IDO5LIDO5L is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 67 nM.
Coptisine chlorideCoptisine chloride is an effective and non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM. Coptisine chloride is an effective H1N1 neuraminidase (NA-1) inhibitor with IC50 of 104.6 μg/mL, which can be used for influenza A virus (H1N1) infection.
Coptisine-SulfateCoptisine Sulfate is an alkaloid isolated from coptis coptidis. It is an effective non-competitive IDO inhibitor with Ki value of 5.8 μM and IC50 value of 6.3 μM.
PalmatinePalmatine is an orally active and irreversible IDO-1 inhibitor. Palmatine ameliorates colitis induced by Dextran Sulphate Sodium Salt (DSS) by reducing colon injury, preventing intestinal microbiome imbalance and regulating tryptophan catabolism. Palmatine has potential for colitis research.

Keywords: Coptisine, Coptisin supplier, IDO, inhibitors, activators

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