Helen Frankenthaler Foundation

Custom Peptides for Cosmetics

The 13 Best Peptide Serums for Firm, Glowy, “Botox-Free” Skin

The 13 Best Peptide Serums for Firm, Glowy, “Botox-Free” Skin

Skinceuticals P-Tiox Serum

Pros
  • Developed to work synergistically with neurotoxins to address areas traditionally considered “off-label” for injections
  • Backed by clinical trials where testers saw improvement more quickly than other peptide products (in as little as one week)
Cons
  • Expensive (especially relative to the size of the bottle and the recommended use of 4 to 6 drops twice a day)
  • Won’t work on very deep-set wrinkles

Why we love it: This is the formula you want if you’re looking for a Botox in a bottle-like effect. It contains neuro-inhibitory peptides, which are known expression line interruptors. This serum isn't going to do the heavy lifting of injectables (no topical can), but it’s a solid in-between solution and great at targeting areas of the face that Botox isn’t officially approved for, like lines around the mouth. It’s also perfect for someone looking for something less invasive but would like to see some smoothing. Rounding out the formula, niacinamide and laminaria extract brighten and even your skin tone, while PHA gently exfoliates for better ingredient penetration. “This is nice because it combines gentle resurfacing with antioxidant and anti-wrinkle effects,” says Dr. Edwards.

Cosmo editor review: "A lot of anti-aging serums can feel heavy on my oily, acne-prone skin. But juuuust because I'm not dry doesn't mean I don't wanna prevent wrinkles, dammit. My face immediately drinks up P-Tiox's lightweight, watery consistency—no sticky residue left behind. But I also notice it definitely helps smooth out my skin. I've been using this serum on and off for eight months, and my forehead is so smooth (even though I haven't topped up my Botox in nearly a year)." —BETH GILLETTE, BEAUTY EDITOR

Features at a Glance
Key ingredientsFragrance-free?
Peptides (dipeptide diaminobutyroyl benzylamide diacetate, acetyl hexapeptide-8), niacinamide, laminaria extract, polyhydroxy acids (PHA)Yes

Biossance Squalane Copper Peptide Rapid Plumping Serum

Pros
  • Can be used with other serums if you want to stack for multiple skin benefits
  • Lightweight, fast-absorbing formula
Cons
  • The bottle and dropper can get a little slippery during application

Why we love it: Sometimes the key to an effective peptide serum is what other skin-loving ingredients it’s packaged with, especially if your skin is on the sensitive side. Dr. Edwards calls this one from Biossance a “smart pairing,” thanks to its copper peptides and sugarcane-derived squalane combo, since squalane is a stable, skin-soothing emollient. “The emollient helps buffer irritation and maintain barrier integrity, which might preserve peptide function,” adds Dr. Edwards. While the “rapid plumping” effect is likely from the humectants in the formula, the peptides present will gradually help increase cell turnover. That means a firmer, healthier-looking complexion in just a few months.

Cosmo editor review: "I’ve been using this serum on and off since it came out a few years back, typically during the winter, and it always gives me an instant volume boost and takes care of any dry patches that have popped up. It has a lightweight gel-like texture so it absorbs into the skin quickly, leaving behind radiance without any residue." — DANIELLE BLUNDELL, CONTRIBUTING BEAUTY WRITER

Features at a Glance
Key ingredientsFragrance-free?
Copper peptides, paracress extract, ectoin, hyaluronic acid, polyglutamic acid (PGA), and sugarcane squalaneYes

The Inkey List Collagen Peptide Serum

Pros
  • Layers nicely with other skincare and makeup without pilling
  • Lightweight texture glides onto skin seamlessly
Cons
  • The bottle is small, and the seal can be leaky
  • The wrinkle-erasing effects aren’t super dramatic

Why we love it: Topical collagen is too large to penetrate the skin’s surface, but that’s not a problem for The INKEY List’s Collagen Peptide Serum. That’s because it uses matrixyl, a much smaller and well-researched signal peptide, alongside a dual peptide complex, to stimulate collagen and elastin production below the surface of the skin. The result? A more hydrated and plump appearance instantly, and with regular use over time, a slightly more snatched, smooth complexion. Dr. Edwards says it's a good choice for someone just starting out with peptides because it punches above its weight price-wise.

Cosmo editor review: "I love The Inkey List’s no-frills products because they’re ideal for keeping my routine simple for my acne-prone skin. This watery serum is a nice collagen-boosting step when my skin needs a little extra something. It’s not as heavy-duty as other peptide serums, but it does the job for a fraction of the price " —JASMINE HYMAN, ASSISTANT BEAUTY EDITOR

Features at a Glance
Key ingredientsFragrance-free?
Matrixyl 3000 peptide complex (palmitoyl dipeptide-5 diaminobutyroyl hydroxythreonine, palmitoyl dipeptide-5 diaminohydroxybutyrate, palmitoyl tetrapeptide-7, palmitoyl tripeptide-1), hyaluronic acid, radish rootYes

SkinMedica TNS Advanced+ Serum