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Forms: Exemestane (Aromasin) 25 mg tablets
Quantity: 30-300 pills
Type: Aromasin (Exemestane) brand and generics
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Aromasin (Exemestane) is an aromatase inhibitor indicated for:
Recommended dose: one 25 mg exemestane tablet once daily after a meal.
Aromasin (Exemestane) tablets 25 mg.
Clinical trials have been conducted with exemestane given as a single dose to healthy female volunteers at doses as high as 800 mg and daily for 12 weeks to postmenopausal women with advanced breast cancer at doses as high as 600 mg. These dosages were well tolerated. There is no specific antidote to overdosage and treatment must be symptomatic. General supportive care, including frequent monitoring of vital signs and close observation of the patient, is indicated. A male child (age unknown) accidentally ingested a 25-mg tablet of exemestane. The initial physical examination was normal, but blood tests performed 1 hour after ingestion indicated leucocytosis (WBC 25000/mm3 with 90% neutrophils). Blood tests were repeated 4 days after the incident and were normal. No treatment was given. In mice, mortality was observed after a single oral dose of exemestane of 3200 mg/kg, the lowest dose tested (about 640 times the recommended human dose on a mg/m2 basis). In rats and dogs, mortality was observed after single oral doses of exemestane of 5000 mg/kg (about 2000 times the recommended human dose on a mg/m2 basis) and of 3000 mg/kg (about 4000 times the recommended human dose on a mg/m2 basis), respectively. Convulsions were observed after single doses of exemestane of 400 mg/kg and 3000 mg/kg in mice and dogs (approximately 80 and 4000 times the recommended human dose on a mg/m2 basis), respectively.
Patients with a known hypersensitivity to the drug or to any of the excipients.
adverse reactions occurring in >= 10% of patients in any treatment group were hot flushes, fatigue, arthralgia, headache, insomnia, increased sweating. Discontinuation rates due to AEs were similar between Aromasin and tamoxifen. Incidences of cardiac ischemic events (myocardial infarction, angina, and myocardial ischemia) were exemestane 1.6%, tamoxifen 0.6%. Incidence of cardiac failure: Aromasin (Exemestane) 0.4%, tamoxifen 0.3% (6, 6.1).
most common adverse reactions were mild to moderate and included hot flushes, nausea, fatigue, increased sweating, increased appetite. To report suspected adverse reactions, contact Pfizer Inc. or your local FDA.
Strong CYP 3A4 inducers: concomitant use of strong CYP 3A4 inducers decreases exemestane exposure. Increase the Aromasin (Exemestane) dose to 50 mg.
Related medications: Arimidex 1 mg tablets, Premarin tablets.
Advise not to breastfeed.
Safety and effectiveness in pediatric patients have not been established.
The AUC of exemestane was increased in subjects with moderate or severe hepatic impairment (Childs-Pugh B or C). However, based on experience with exemestane at repeated doses up to 200 mg daily that demonstrated a moderate increase in non life-threatening adverse reactions, dosage adjustment does not appear to be necessary.
The AUC of exemestane was increased in subjects with moderate or severe renal impairment (creatinine clearance < 35 mL/min/1.73 m2). However, based on experience with exemestane at repeated doses up to 200 mg daily that demonstrated a moderate increase in non life-threatening adverse reactions, dosage adjustment does not appear to be necessary.
Advise patients that Aromasin lowers the level of estrogen in the body. This may lead to reduction in bone mineral density (BMD) over time. The lower the BMD, the greater the risk of osteoporosis and fracture.
Advise patients that they should not take estrogen-containing agents while they are taking Exemestane (Aromasin) tablets as these could interfere with its pharmacologic action.
Advise patients that this medication is not for use for the treatment of breast cancer in premenopausal women.
Advise pregnant women and females of reproductive potential that exposure during pregnancy or within 1 month prior to conception can result in fetal harm. Advise females to inform their healthcare provider of a known or suspected pregnancy. Advise females of reproductive potential to use effective contraception while taking Aromasin and for 1 month after the last dose.
Advise women not to breastfeed during treatment with this medicine and for 1 month after the last dose.
To purchase Aromasin (Exemestane) 25 mg tablets from reliable online pharmacies and drugstores at low prices please use resources described above on this webpage. Here is a list of popular medications containing exemestane as a main active pharmaceutical ingredient; their trade names, forms, doses, companies - manufacturers, distributors, suppliers, researchers and developers:
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