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Survodutide (BI 456906) is a potent and selective dual glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) agonist with EC50 values of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide is a 29 amino acid peptide that is a potent acylated peptide containing C18 fatty acids. Survodutide exerts a potent anti-obesity effect by increasing energy expenditure and reducing food intake.
Survodutide (formerly BI 456906) is a glucagon/GLP-1 receptor dual agonist that received Fast Track designation from the U.S. Food and Drug Administration in 2021 for the treatment of MASH with fibrosis.
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