Fibrinogen Binding Inhibitory Peptide product

Product Information

• Product Name Fibrinogen-Binding Inhibitor Peptide
• Documents
• Sequence Shortening HHLGGAKQAGDV
• Sequence H-His-His-Leu-Gly-Gly-Ala-Lys-Gln-Ala-Gly-Asp-Val-OH
• Length (aa) 12
• Peptide Purity (HPLC) 97.5%
• Molecular Formula C 50 H 80 N 18 O 16
• Molecular Weight 1189.3
• CAS No. 89105-94-2
• Source Synthetic
• Form Powder
• Description This synthetic dodecapeptide represents the specific platelet receptor recognition site of the human fibrinogen γ chain (residues 400-411). It is a potent inhibitor of the binding of fibrinogen, fibronectin, and von Willebrand factor to thrombin- or ADP-stimulated platelets. The peptide has also been used in studying phosphorylation processes associated with platelet activation.
• Storage Guidelines Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
• References
  • S.Timmons et al., Proc. Natl. Acad. Sci. USA, 81, 4935 (1984)
  • E.F.Plow et al., J. Biol. Chem., 259, 5388 (1984)
  • Z.M.Ruggeri et al., Proc. Natl. Acad. Sci. USA, 83, 5708 (1986)
  • S.Williams and H.Gralnick, Thromb. Res., 46, 457 (1987)
  • J.E.Ferrell, Jr. and G.S.Martin, Proc. Natl. Acad. Sci. USA, 86, 2234 (1989)
  • R.R.Hantgan et al., Thromb. Haemost., 68, 694 (1992)

About TFA salt

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight:

The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility:

TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays:

For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

Molar Concentration Calculator

Dilution Calculator

Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Peptide Property

• Analysed Sequence: H-H H L G G A K Q A G D V-OH
• Chemical Formula: C 50 H 80 N 18 O 16
• Sequence length: 12
• Extinction coefficient: 0 M-1 cm-1
• GRAVY: -0.58
• Mw average: 1189.27
• Theoretical pI: 7.88
• Data Source: Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2 H, 15 N, and 13 C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.