Helen Frankenthaler Foundation

Fibrinopeptide B bovine supplier

Human fibrinopeptide B (hFpB)

rebaudioside b molecular research

Product Information

  • Product Name Human fibrinopeptide B (hFpB)
  • Documents
  • Sequence Shortening Pyr-GVNDNEEGFFSAR-OH
  • Sequence Pyr-Gly-Val-Asn-Asp-Asn-Glu-Glu-Gly-Phe-Phe-Ser-Ala-Arg-OH
  • Length (aa) 14
  • Peptide Purity (HPLC) 95.69%
  • Molecular Formula C 66 H 93 N 19 O 25
  • Molecular Weight 1552.55
  • CAS No. 36204-23-6
  • PubChem CID 16132131
  • Source Synthetic
  • Form Powder
  • Description Human fibrinopeptide B (hFpB) is a peptide of 14 amino acids that is released from the amino-terminus of the Bβ-chains of fibrinogen by thrombin. It is also contained within the primary plasmin cleavage product of fibrinogen, Bβ1-42. hFpB stimulates the migration of PMN, with a peak effect occurring at 10^-8 M. This chemotactic activity is blocked by preincubating hFpB with antiserum to hFpB. PMN chemotaxis to hFpB does not involve the receptors for C5a, LTB4, or fMLP. hFpB also exerts chemotactic activity for fibroblasts, and its potency is comparable to that observed with PDGF under identical test conditions. hFpB causes an increase in cytoskeletal-associated actin in PMN within 30 s, showing a clear dose response with the maximal effect at 10^-8 M. However, it does not cause PMN aggregation, release of lysosomal enzymes (lysozyme and β-glucuronidase), or the production of superoxide anion. The chemotactic potency of hFpB for PMN is equivalent to that of C5a, LTB4, and fMLP, and its chemotactic activity for PMN occurs in the same concentration range as these other well-defined PMN chemoattractants.
  • Storage Guidelines Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Senior RM, Skogen WF, Griffin GL, Wilner GD. Effects of fibrinogen derivatives upon the inflammatory response. Studies with human fibrinopeptide B. J Clin Invest. 1986 Mar;77(3):1014-9. doi: 10.1172/JCI112353. PMID: 3005361; PMCID: PMC423507.

About TFA salt

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

  • Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
  • Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
  • In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

Molar Concentration Calculator

Dilution Calculator
Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

  • Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.
  • Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.
  • Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2 H, 15 N, and 13 C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.