Helen Frankenthaler Foundation

Gastrin-1 rat product

Gastrin I (human) | CCK2 Receptors

winstrol 20mg cas no 10418 03 8 molecular research

Gastrin I (human)

Cat. No. 3006

Pricing and Availability

PricingAvailabilityQty
1 mg / $449In Stock

Description

Selective CCK 2 agonist

Purity

≥95% (HPLC)

Biological Activity

Gastrin I (human) is an endogenous peptide produced in the stomach that acts as a selective CCK2 receptor agonist. Gastrin I stimulates gastric acid secretion and has a mitogenic effect on gastric cells. Gastrin I stimulates gastric epithelial cell proliferation and histamine secretion (EC 50 values are 6.2 pM and 0.014 nM, respectively). Gastrin I is also used in the culture of stomach, intestine and pancreas organoids.

Technical Data

PropertyValue
M. Wt2098.22
FormulaC 97 H 124 N 20 O 31 S
SequenceXGPWLEEEEEAYGWMDF (Modifications: X = Glp, Phe-17 = C-terminal amide)
StorageStore at -20°C
Purity≥95% (HPLC)
CAS Number10047-33-3
PubChem ID16162108
InChI KeyGKDWRERMBNGKCZ-RNXBIMIWSA-N
Smiles[H]N1[C@@H](CCC1=O)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(N)=O
Technical Note

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Soluble to 1 mg/ml in 1% Ammonia with sonication

References

References are publications that support the biological activity of the product.

  • Noble et al (1999) International union of pharmacology XXI. Structure, distribution, and functions of cholecystokinin receptors. Pharmacol.Rev. 51 745 PMID:10581329
  • Blandizzi et al (1999) CCK1 and CCK2 receptors regulate gastric pepsinogen secretion. Eur.J.Pharmacol. 373 71 PMID:10408253
  • Sato et al (2015) SnapShot: Growing Organoids from Stem Cells. Cell 161 1700 PMID:26091044
  • Mahe et al (2014) Establishment of gastrointestinal epithelial organoids Curr.Protoc. Mouse Biol. 3 217 PMID:25105065
  • Bartfeld et al (2015) In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infection. Gastroenterology 148 126 PMID:25307862
  • Kidd et al (2007) A comparison of the effects of gastrin, somatostatin and dopamine receptor ligands on rat gastric enterochromaffin-like cell secretion and proliferation. Regul.Pept. 143 109 PMID:17531331