Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). Three subtypes of bombesin receptor are known: BB 1, BB 2 and an orphan receptor (bb 3).
Bombesin receptors are activated by the endogenous ligands gastrin-releasing peptide (GRP), neuromedin B (NMB) and GRP18-27 (neuromedin C). There are three subtypes of the bombesin receptor. BB 1 was previously known as the NMB receptor while BB 2 was previously known as the GRP receptor. BB 3 is designated an orphan receptor, however it has been shown to respond to NMB peptides, albeit at a lower potentcy than BB 1.
The receptors are G q/11-coupled and are involved in the regulation of many biological functions including sensory transmission, thermoregulation, feeding and pituitary, gastric and pancreatic secretion. They may also be involved in tissue development, proliferation and differentiation.
Tocris offers the following scientific literature for Bombesin Receptors to showcase our products. We invite you to request* your copy today!
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
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