Helen Frankenthaler Foundation

Glepaglutide CAS NO.914009-86-2

GLP-1 (7-36) | Glucagon-like peptide 1 (7-36)

glp 1 7 36 cas no 89750 14 1 powder macro

Glucagon-like peptide 1 (7-36) amide (human, rat)

Cat. No. 2082

Description

Potent insulinotropic peptide

Alternative Names

GLP-1 (7-36) amide

Purity

≥95% (HPLC)

Biological Activity

Glucagon-like peptide 1 (7-36) amide (human, rat) is a potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (K d = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.

Technical Data

PropertyValue
M. Wt3297.67
FormulaC 149 H 226 N 40 O 45
SequenceHAEGTFTSDVSSYLEGQAAKEFIAWLVKGR (Modifications: Arg-30 = C-terminal amide)
StorageStore at -20°C
Purity≥95% (HPLC)
CAS Number107444-51-9
PubChem ID16133831
InChI KeyDTHNMHAUYICORS-KTKZVXAJSA-N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility Data

Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

  • Goke and Conlon (1988) Receptors for glucagon-like peptide-1(7-37) amide on rat Insoma-derived cells. J.Endocrinol. 116 357 PMID:2832504
  • Turton et al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69 PMID:8538742
  • Perfetti and Merkel (2000) Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717 PMID:11124853
  • Perry et al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881 PMID:12183643