GLP-1 agonist biotin conjugate

GLP-1 Semaglutide 10mg

GLP-1 Semaglutide 10mg is a synthetic polypeptide precision-engineered for studies targeting GLP-1 receptor (GLP-1R) activation. It shares 94% structural similarity with native human GLP-1 but includes critical modifications—such as the substitution of alpha-aminoisobutyric acid (Aib) at position 8—that significantly increase its stability against dipeptidyl peptidase-4 (DPP-4) degradation.

• Receptor Affinity: Researched as a potent GLP-1R agonist that stimulates intracellular cyclic adenosine monophosphate (cAMP) production.
• Extended Half-Life: Features a C-18 fatty diacid acylation at position 26, allowing for high affinity with albumin and an estimated biological half-life of 165 hours in research settings.
• Insulin Signaling: Studied for its role in the PI3K/Akt pathway, which is essential for investigating the viability of pancreatic beta-cell analogs.
• CNS Regulation: Evaluated for its ability to cross the blood-brain barrier and modulate energy balance through receptors in the hypothalamus.

Key Research Applications of GLP-1 Semaglutide 10mg

This peptide is primarily used in laboratory models investigating:

• Metabolic Homeostasis: Studies on glucose-dependent insulin secretion and the suppression of glucagon activity in cellular analogs.
• Neuroprotective Dynamics: Research into neurogenesis, reduction of oxidative stress, and modulation of neuroinflammation in CNS models.
• Hepatoprotective Research: Investigations into the stabilization of liver enzymes and the progression of fatty tissue markers in NASH models.
• Vascular Integrity: Evaluation of endothelial function and the preservation of blood-brain barrier (BBB) structural integrity.

GLP-1 Semaglutide 10mg Product Specifications

Product Care & Handling Guidelines

Proper storage is required to maintain the stability of the Semaglutide polypeptide.

• Unreconstituted (Powder): Store in a dry, dark environment. Long-term storage is optimal at -20°C to -80°C.
• Reconstituted (Liquid): Refrigerate at 2°C to 8°C; researchers typically use within 7 to 14 days for maximum stability.
• Handling Note: Peptides are sensitive to mechanical stress. Use gentle swirling during reconstitution and avoid vigorous shaking.

References & Resources

NCBI PubMed: https://www.frankenthalerfoundation.org

NCBI PMC: https://www.frankenthalerfoundation.org

NCBI PMC: https://www.frankenthalerfoundation.org

PubChem: https://www.frankenthalerfoundation.org

NCBI PMC: https://www.frankenthalerfoundation.org

Laboratory Research Use Only Notice

This product is strictly intended for in vitro and non-clinical laboratory research purposes only. It is not for human consumption, veterinary diagnostic, or therapeutic use. Statements regarding the biochemical potential of this compound have not been evaluated by the Food and Drug Administration (FDA). Researchers must follow established laboratory safety protocols.