Catalog Number: P001729
Sequence: Gly-Ser-Ser(n-octanoyl)-Phe-Leu-Ser-Pro-Glu-His-Gln-Arg-Val-Gln-Gln-Arg-Lys-Glu-Ser-Lys-Lys-Pro-Pro-Ala-Lys-Leu-Gln-Pro-Arg
Synonym: Ghrelin, human
CAS Number: 258279-04-8
Molecular Weight: 3370.9
Molecular Formula: C149H249N47O42
Refer to Certificate of Analysis for lot specific data (including water content).
The main structural feature of ghrelin is the octanoyl group attached to the Ser3 residue. The octanoyl group is essential for stimulating growth hormome release. Recently it was reported that ghrelin may be important for memory control. Ghrelin is produced by cells lining the fundus of the human stomach and epsilon cells of the pancreas. Levels of ghrelin rise before meals and decrease after meals. It stimulates the appetite and increases fat mass. Ghrelin also stimulates the release of growth hormone from pituitary cells and plays a significant role in neurotrophy. It is essential for the processes of learning. It also accelerates wound healing and controls inflammation. In addition, ghrelin also activates the mesolimbic cholinergic-dopaminergic reward link, a circuit that communicates the hedonic and reinforcing aspects of natural rewards, such as food and addictive substances, such as ethanol. Ghrelin has been shown to defend against the depressive-like effects of chronic stress.
M.W.: 3370.9
