GLP-2 peptide for intestinal research

Glucagon-like peptide 1 (7-36) amide (human, rat)

Cat. No. 2082

Description

Potent insulinotropic peptide

Alternative Names

GLP-1 (7-36) amide

Purity

≥95% (HPLC)

Biological Activity

Glucagon-like peptide 1 (7-36) amide (human, rat) is a potent glucose-dependent insulinotropic peptide produced by post-translational processing of proglucagon in intestinal L-cells. Displays high affinity for GLP-1 receptors expressed in rat insulinoma-derived RINm5F cells (K d = 204 pM). Stimulates insulin gene transcription and secretion in pancreatic β-cells. Displays antiapoptotic effects in hippocampal neurons and reduces food intake in fasted rats following central administration.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility Data

Soluble to 1 mg/ml in water

References

References are publications that support the biological activity of the product.

• Goke and Conlon (1988) Receptors for glucagon-like peptide-1(7-37) amide on rat Insoma-derived cells. J.Endocrinol. 116 357 PMID:2832504
• Turton et al (1996) A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 379 69 PMID:8538742
• Perfetti and Merkel (2000) Glucagon-like peptide-1: a major regulator of pancreatic β-cell function. Eur.J.Endocrinol. 143 717 PMID:11124853
• Perry et al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881 PMID:12183643