GM-CSF antagonist development tool

Human GM-CSF Recombinant Protein

Product Details

RGMCSF20

Applications

Tested Dilution

Publications

Bioactivity (Bioactivity)

Assay-dependent

Product Specifications

Species

Human

Expression System

E. coli

Amino acid sequence

Human GM-CSF recombinant protein contains 128 amino acids

Molecular weight

14.6 kDa

Class

Recombinant

Type

Protein

Activity

ED50 ≤ 0.1 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.

Conjugate

Unconjugated

Form

Lyophilized

Amount

20 µg

Purification

purified

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

This product cross-reacts with bacteria, Mouse, Leech, Porcine, and Chicken GM-CSF.

For dilution, use a buffer containing carrier protein, e.g. PBS with 1% BSA or a neutral media containing 10% FCS and freeze in aliquots at -70°C. Sterile-filtered through a 0.2 micron filter.

Reconstitute with 0.5 mL of distilled water.

Target Information

The GM-CSF gene encodes for a cytokine that regulates the production, differentiation, and function of macrophages and granulocytes. The active form of the protein exists as a homodimer in the extracellular space. This gene is located in a cluster of related genes at the chromosome region 5q31, which has been associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include interleukins 4, 5, and 13. The gene is involved in promoting tissue inflammation. Elevated levels of cytokines, including the one produced by this gene, have been observed in SARS-CoV-2 infected patients with acute respiratory distress syndrome. Mice that lack this gene or its receptor have been shown to develop pulmonary alveolar proteinosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication? Let us know so we can reference it here.

Bioinformatics

Protein Aliases: colony stimulating factor 2 (granulocyte-macrophage); Colony-stimulating factor; CSF; GM-CSF; granulocyte macrophage colony stimulating factor; granulocyte macrophage-colony stimulating factor; Granulocyte-macrophage colony-stimulating factor; granulocyte/macrophage colony-stimulating factor; M-GM-CSF; MGC131935; MGC138897; MGC151255; MGC151257; molgramostim; Molgramostin; Sargramostim

Gene Aliases: CSF; CSF2; GMCSF

UniProt ID:(Human) P04141

Entrez Gene ID:(Human) 1437

Disclaimer

Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fi