Helen Frankenthaler Foundation

GnRH agonist supplier

Gonadotropin-releasing hormone agonist | DrugBank

Gonadotropin-releasing hormone agonist

Accession Number DBCAT002742 (DBCAT000050, DBCAT002088, DBCAT002435)

Description

A decapeptide that stimulates the synthesis and secretion of both pituitary gonadotropins, LUTEINIZING HORMONE and FOLLICLE STIMULATING HORMONE. GnRH is produced by neurons in the septum PREOPTIC AREA of the HYPOTHALAMUS and released into the pituitary portal blood, leading to stimulation of GONADOTROPHS in the ANTERIOR PITUITARY GLAND.

Drugs

DrugDrug Description
BuserelinA LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females.
DeslorelinDeslorelin acetate is an injectable gonadotropin releasing hormone super-agonist also known as an LHRH agonist. It stops the production of sex hormones.
GonadorelinA synthetic GnRH used to test the function of gonadotropes and the pituitary.
GoserelinA synthetic analog of luteinizing hormone-releasing hormone used to treat breast cancer and prostate cancer by reducing secretion of gonadotropins from the pituitary.
HistrelinA GnRH agonist found in subcutaneous implants used for the treatment of pediatric patients with central precocious puberty and the palliative treatment of advanced prostate cancer.
LeuprolideA peptide-based GnRH receptor superagonist used for the palliative treatment of prostate cancer, uterine leiomyomata, endometriosis, and central precocious puberty.
NafarelinA gonadotropin releasing hormone agonist used to treat central precocious puberty.
TriptorelinA GnRH agonist indicated for the palliative treatment of advanced prostate cancer.

Drugs & Drug Targets

DrugTargetType
BuserelinLutropin-choriogonadotropic hormone receptortarget
BuserelinGonadotropin-releasing hormone receptortarget
BuserelinAromataseenzyme
GonadorelinGonadotropin-releasing hormone receptortarget
GonadorelinPutative gonadotropin-releasing hormone II receptortarget
GoserelinLutropin-choriogonadotropic hormone receptortarget
GoserelinGonadotropin-releasing hormone receptortarget
GoserelinProgonadoliberin-1target
HistrelinGonadotropin-releasing hormone receptortarget
LeuprolideGonadotropin-releasing hormone receptortarget
LeuprolideProgonadoliberin-1target
NafarelinGonadotropin-releasing hormone receptortarget
NafarelinPutative gonadotropin-releasing hormone II receptortarget
TriptorelinGonadotropin-releasing hormone receptortarget