Helen Frankenthaler Foundation

gp100 peptide supplier

Pep-20 peptide

Pep-20 peptide

Not For Human Use, Lab Use Only.

Product Information

Product Name: Pep-20 peptide

Documents
  • COA/MS/HPLC Report
  • Handling and Storage of Synthetic Peptides
  • Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Details
PropertyValue
Sequence ShorteningH-AWSATWSNYWRH-OH
SequenceH-Ala-Trp-Ser-Ala-Thr-Trp-Ser-Asn-Tyr-Trp-Arg-His-OH
Length (aa)12
Peptide Purity (HPLC)99.42%
Molecular FormulaC74 H93 N21 O18
Molecular Weight1564.73
SourceSynthetic
FormPowder
DescriptionPep-20 peptide (AWSATWSNYWRH) was able to block CD47/SIRPα pathway by binding to CD47. An in vitro study confirmed the ability of Pep-20 to enhance macrophage phagocytic activity against a range of murine and human cancer cell lines as well as promoting macrophage-mediated development of antitumor CD8+ T cells. Antitumor activity of Pep-20 was also observed in a CT26 tumor mouse model, where the Pep-20 treated group showed tumor suppression and increased overall survival.
Storage GuidelinesNormally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides.
References
  • Wang H, Sun Y, Zhou X, Chen C, Jiao L, Li W, et al.. CD47/SIRPα Blocking Peptide Identification and Synergistic Effect With Irradiation for Cancer Immunotherapy. J Immunother Cancer (2020) 8(2):e000905. doi: 10.1136/jitc-2020-000905
About TFA salt

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

Related Products / Services

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2 H, 15 N, and 13 C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"