Definition
Gastrointestinal hormones are hormones produced from specialized endocrine cells of the stomach, pancreas and small intestine, which are secreted directly into the bloodstream. Here, they promote the physical process of food digestion, detect harmful substances and generate responses that protect against harmful substances. Examples of gastrointestinal hormones are ghrelin, amylin and glucagon-like peptides 1 and 2.
Balancing cholesterol metabolism in the liver and gut: perspectives in health and disease
In this Review, Brown and colleagues describe the latest insights into the role of cholesterol synthesis and metabolism in the gut and liver, and implications in diseases such as metabolic dysfunction-associated steatotic liver disease, hepatocellular carcinoma and colorectal cancer.
Reviews 09 Jan 2026 Nature Reviews Gastroenterology & Hepatology
P: 1-16
Distinct fasting and postprandial bile acid responses following Roux-en-Y and one-anastomosis gastric bypass
Research Open Access 05 Jan 2026 International Journal of Obesity
P: 1-10
Intestinal adaptation to cold-induced metabolic demand and feeding requires GLP-1R and GLP-2R signalling
Chronic cold stress in Glp1r -/- Gipr -/-, Glp1r -/- Glp2r -/-, and Glp2r -/- mice revealed distinct and overlapping roles for GLP-1R and GLP-2R in the expansion of the intestinal absorptive surface area expansion in response to chronic cold stress.
Research Open Access 04 Dec 2025 Communications Biology
Volume: 9, P: 25
The role of broad bean albumin 1b on GIP and GLP-1 mediated alterations to glucose metabolism in diabetic mice
Research Open Access 23 Jun 2025 npj Science of Food
Volume: 9, P: 110
Human adaptation response to obesity
Reviews 27 Apr 2025 International Journal of Obesity
Volume: 49, P: 1502-1510
Alterations in intestinal bile acid transport provide a therapeutic target in patients with post-bariatric hypoglycaemia
FGF19 increase in post-bariatric hypoglycaemia is mediated by bile acid dysregulation, and can be countered by inhibiting bile acid transport.
Research 04 Apr 2025 Nature Metabolism
Volume: 7, P: 792-807
H 2 S as a metabolic saboteur
In this issue of Nature Metabolism, Qi and colleagues show that the gut microbiota members Desulfovibrio spp. produce hydrogen sulfide, which disrupts host metabolism by suppressing GLP-1 production in mice. The study unveils a microbial mechanism that affects metabolic health.
News & Views 19 Jul 2024 Nature Metabolism
Volume: 6, P: 1431-1432
Glutamate from the microbiome controls host metabolism
In an attempt to investigate the role of enteroendocrine cells in the colon using elegant, targeted depletion tools, the authors of a study published in this issue of Nature Metabolism highlight the orexigenic role of a bacterial metabolite in the intestinal lumen, l-glutamate.
News & Views 22 May 2024 Nature Metabolism
Volume: 6, P: 987-989
CAMK1D required for ghrelin-mediated food intake
Research Highlights 27 Jun 2023 Nature Reviews Endocrinology
Volume: 19, P: 499
Gene-edited organoids enable sensitive assessment of peptide hormone variation
Research Highlights 01 Dec 2022 Nature Reviews Endocrinology
Volume: 19, P: 64
Mechanosensitive release of 5-HT from specialized intestinal epithelial cells
Research Highlights 23 Nov 2022 Nature Reviews Gastroenterology & Hepatology
Volume: 20, P: 4
Mapping neuron functions in the gut–brain axis
Research Highlights 07 Jun 2021 Nature Reviews Endocrinology
Volume: 17, P: 448
