hicken ANF peptide

C-type natriuretic peptide (1-22) (human, rat, swine)

Cat. No. 3520

Description

Endogenous peptide agonist at NPR2

Purity

≥95% (HPLC)

Pricing and Availability

Biological Activity

C-type natriuretic peptide (1-22) (human, rat, swine) is an endogenous peptide found in plasma and cerebrospinal fluid. Behaves as an agonist at natriuretic peptide receptor NPR2 (NPRB) and exhibits affinity for NPR3 (NPRC). Inhibits L-type calcium currents in myocytes and exhibits antiproliferative effects in cardiac fibroblasts in vitro. Regulates cartilage homeostasis, body fluid volume and exhibits vasodilatory activity in vivo.

Technical Data

• M. Wt 2197.61
• Formula C 93 H 157 N 27 O 28 S 3
• Sequence GLSKGCFGLKLDRIGSMSGLGC (Modifications: Disulfide bridge: 6-22)
• Storage Store at -20°C
• CAS Number 127869-51-6
• PubChem ID 16179407
• InChI Key UHSBKBYWHCBDCJ-DYGWFTAGSA-N
• Smiles [H]NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@H]1CSSC[C@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CC2=CC=CC=C2)NC1=O)[C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solubility Soluble to 1 mg/ml in water

Product Datasheets

Certificate of Analysis / Product Datasheet Safety Datasheet

References

References are publications that support the biological activity of the product.

• Suga et al (1992) Receptor selectivity of natriuretic peptide family, atrial natriuretic peptide, brain natriuretic peptide, and C-type natriuretic peptide. Endocrinology 130 229 PMID:1309330
• Pejchalova et al (2007) C-natriuretic peptide: An important regulator of cartilage. Mol.Genet.Metab. 92 210 PMID:17681481
• Rose and Giles (2008) Natriuretic peptide C receptor signalling in the heart and vasculature. J.Physiol. 586 353 PMID:18006579

If you know of a relevant reference for C-type natriuretic peptide (1-22) (human, rat, swine), please let us know.

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