High-purity opioid peptide for research

Nature Volume 267 Issue 5611 Pages 495-499 Year 1977

publications 2,485 supporting 24 mentioning 690 contrasting 4 Smart Citations 2,485 24 690 4 Citing Publications Supporting Mentioning Contrasting

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Summary:

It is concluded that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.

Abstract:

Opioid peptides were assayed by inhibition of 3H-naloxone and 3H-leu-enkephalin binding in brain homogenates and by depression of contractions of the guinea pig ileum and mouse vas deferens. We conclude that the opioid peptidergic system has agonists of different characteristics which interact with more than one type of receptor.

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