Human mouse rat MCH agonist

MCH (human, mouse, rat) | Melanin-concentrating hormone | Tocris Bioscience

Cat. No. 3806

Description

Potent endogenous MCH agonist

Alternative Names

Melanin-concentrating hormone (human,mouse,rat)

Purity

≥95% (HPLC)

Biological Activity

MCH (human, mouse, rat) is a potent endogenous agonist at melanin-concentration hormone (MCH) receptors (IC 50 values are 0.3 and 1.5 nM and EC 50 values are 3.9 and 0.1 nM at MCH 1 and MCH 2 receptors respectively). Increases food intake in vivo.

Technical Data

• M. Wt 2386.84
• Formula C 105 H 160 N 30 O 26 S 4
• Sequence DFDMLRCMLGRVYRPCWQV (Modification: Disulfide bridge: 7-16)
• Storage Store at -20°C
• Purity≥95% (HPLC)
• CAS Number 128315-56-0
• PubChem ID 24868207
• InChI Key MWLPXSMFEPHETN-QRXCLJFASA-N
• Smiles [H]N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCSC)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility Data

Solubility Soluble to 1 mg/ml in water

References

Sailer et al (2001) Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc.Natl.Acad.Sci.USA 98 7564