Helen Frankenthaler Foundation

Ion channel research peptide

Synthetic peptides as models for ion channel proteins

mangostin molecular research

Synthetic peptides as models for ion channel proteins

Article April 1, 1993

Authors

  • Karin S. Akerfeldt
  • Jim D. Lear
  • Zelda R. Wasserman
  • Laura A. Chung
  • William F. DeGrado

Publication

Accounts of Chemical Research

Cite this: Acc. Chem. Res. 1993, 26, 4

Published April 1, 1993

research-article

ACS Publications

Note: In lieu of an abstract, this is the article's first page.

Cited By

This article is cited by 196 publications.

Citation
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2. Nafiseh Olov, Shirin Nour, Alexander R. Harris, Dan Li, Mark Cook, Richard J. Williams, Samuel Cheeseman, David R. Nisbet. Using Nanoscale Passports To Understand and Unlock Ion Channels as Gatekeepers of the Cell. ACS Nano 2024, 18 (34) , 22709-22733.
3. Zhao-Jun Yan, Ya-Wei Li, Maohua Yang, Yong-Hong Fu, Rongrong Wen, Wenning Wang, Zhan-Ting Li, Yunxiang Zhang, Jun-Li Hou. Voltage-Driven Flipping of Zwitterionic Artificial Channels in Lipid Bilayers to Rectify Ion Transport. Journal of the American Chemical Society 2021, 143 (30) , 11332-11336.
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5. Katsuya Ichihashi, Daisuke Konno, Takuya Date, Takumi Nishimura, Kseniya Yu. Maryunina, Katsuya Inoue, Toshimi Nakaya, Kazuhiro Toyoda, Yoko Tatewaki, Tomoyuki Akutagawa, Takayoshi Nakamura, Sadafumi Nishihara. Optimizing Lithium Ion Conduction through Crown Ether-Based Cylindrical Channels in [Ni(dmit)2]− Salts. Chemistry of Materials 2018, 30 (20) , 7130-7137.
6. Pengyang Xin, Pingping Zhu, Pei Su, Jun-Li Hou, and Zhan-Ting Li . Hydrogen-Bonded Helical Hydrazide Oligomers and Polymer That Mimic the Ion Transport of Gramicidin A. Journal of the American Chemical Society 2014, 136 (38) , 13078-13081.
7. Lei Chen, Wen Si, Liang Zhang, Gangfeng Tang, Zhan-Ting Li, and Jun-Li Hou . Chiral Selective Transmembrane Transport of Amino Acids through Artificial Channels. Journal of the American Chemical Society 2013, 135 (6) , 2152-2155.
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9. Paraskevi Gkeka and Lev Sarkisov. Interactions of Phospholipid Bilayers with Several Classes of Amphiphilic α-Helical Peptides: Insights from Coarse-Grained Molecular Dynamics Simulations. The Journal of Physical Chemistry B 2010, 114 (2) , 826-839.
10. P. Gkeka and L. Sarkisov. Spontaneous Formation of a Barrel-Stave Pore in a Coarse-Grained Model of the Synthetic LS3 Peptide and a DPPC Lipid Bilayer. The Journal of Physical Chemistry B 2009, 113 (1) , 6-8.
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13. Gabriel A. Cook, Robert Pajewski, Mahalaxmi Aburi, Paul E. Smith, Om Prakash, John M. Tomich, and George W. Gokel. NMR Structure and Dynamic Studies of an Anion-Binding, Channel-Forming Heptapeptide. Journal of the American Chemical Society 2006, 128 (5) , 1633-1638.
14. U. S. Sudheendra and Burkhard Bechinger. Topological Equilibria of Ion Channel Peptides in Oriented Lipid Bilayers Revealed by 15N Solid-State NMR Spectroscopy. Biochemistry 2005, 44 (36) , 12120-12127.
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18. Hitoshi Ishida, Zhi Qi, Masahiro Sokabe, Kiyoshi Donowaki, and Yoshihisa Inoue. Molecular Design and Synthesis of Artificial Ion Channels Based on Cyclic Peptides Containing Unnatural Amino Acids. The Journal of Organic Chemistry 2001, 66 (9) , 2978-2989.
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21. Ernesto Abel, Glenn E. M. Maguire, Oscar Murillo, Iwao Suzuki, Stephen L. De Wall, and George W. Gokel. Hydraphile Channels: Structural and Fluorescent Probes of Position and Function in a Phospholipid Bilayer. Journal of the American Chemical Society 1999, 121 (39) , 9043-9052.
22. Oscar Murillo, Iwao Suzuki, Ernesto Abel, Clare L. Murray, Eric S. Meadows, Takashi Jin, and George W. Gokel. Synthetic Transmembrane Channels: Functional Characterization Using Solubility Calculations, Transport Studies, and Substituent Effects. Journal of the American Chemical Society 1997, 119 (24) , 5540-5549.
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24. Paolo Scrimin, Andrea Veronese, Paolo Tecilla, Umberto Tonellato, Vania Monaco, Fernando Formaggio, Marco Crisma, and Claudio Toniolo. Metal Ion Modulation of Membrane Permeability Induced by a Polypetide Template. Journal of the American Chemical Society 1996, 118 (10) , 2505-2506.
25. Maryam M. Javadpour, Martha M. Juban, Wai-Chun J. Lo, Steven M. Bishop, J. Brannon Alberty, Scott M. Cowell, Calvin L. Becker, and Mark L. McLaughlin. De Novo Antimicrobial Peptides with Low Mammalian Cell Toxicity. Journal of Medicinal Chemistry 1996, 39 (16) , 3107-3113.
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27. Johnson C. Chung and David J. Gross, James L. Thomas and David A. Tirrell, Lorinda R. Opsahl-Ong. pH-Sensitive, Cation-Selective Channels Formed by a Simple Synthetic Polyelectrolyte in Artificial Bilayer Membranes. Macromolecules 1996, 29 (13) , 4636-4641.
28. Wen Zhao, Linlin Shi, Juan Chen, Jingjing Ma, Qingqing Lv, Yonghui Sun, Nan Lv, Xiaoyu Chang, Pengyang Xin. Fast-switching pH-responsive biomimetic ion channels with bidirectional gating control. Chemical Science 2026, 17 (4) , 2273-2280.
29. Ji‐Pan Dong, Hua Liu, Wei Gao, Lehui Xiao, Mo Sun, Jun‐Li Hou. Influence of Charges on Lipid Membrane‐Incorporation Behaviors of Artificial Channels. Chinese Journal of Chemistry 2026, 44 (1) , 139-144.
30. Mizuki Ito, Jun Manabe, Katsuya Inoue, Yin Qian, Xiao‐Ming Ren, Tomoyuki Akutagawa, Takayoshi Nakamura, Sadafumi Nishihara. Solid‐State Ion Exchange of Organic Ammonium Cations in Molecular Crystals. European Journal of Inorganic Chemistry 2025, 28 (4).
31. Mizuki Ito, Jun Manabe, Katsuya Inoue, Takehiro Hirao, Takeharu Haino, Tomoyuki Akutagawa, Kiyonori Takahashi, Takayoshi Nakamura, Sadafumi Nishihara. Single-crystal-to-single-crystal transformation based on ionophore-like transport. Chemistry Letters 2025, 54 (1).
32. Yong-Hong Fu, Yi-Fei Hu, Tao Lin, Guo-Wei Zhuang, Ying-Lan Wang, Wen-Xue Chen, Zhan-Ting Li, Jun-Li Hou. Constructing artificial gap junctions to mediate intercellular signal and mass transport. Nature Chemistry 2024, 16 (9) , 1418-1426.
33. Pengyang Xin, Wenke Ren, Qiuhui Zhu, Jie Wang, Yonghui Sun, Junbiao Chang, Gongming Zhu. Synthetic cation channel: reconstructing the ion permeation pathway of TRPA1 in an artificial system. RSC Advances 2024, 14 (37) , 26933-26937.
34. Linlin Shi, Wen Zhao, Zhihui Jiu, Jingjing Guo, Qiuhui Zhu, Yonghui Sun, Bo Zhu, Junbiao Chang, Pengyang Xin. Redox‐Regulated Synthetic Channels: Enabling Reversible Ion Transport by Modulating the Ion‐Permeation Pathway. Angewandte Chemie 2024, 136 (20).
35. Linlin Shi, Wen Zhao, Zhihui Jiu, Jingjing Guo, Qiuhui Zhu, Yonghui Sun, Bo Zhu, Junbiao Chang, Pengyang Xin. Redox‐Regulated Synthetic Channels: Enabling Reversible Ion Transport by Modulating the Ion‐Permeation Pathway. Angewandte Chemie International Edition 2024, 63 (20).
36. Jue Hou, Chen Zhao, Huacheng Zhang. Bio‐Inspired Subnanofluidics: Advanced Fabrication and Functionalization. Small Methods 2024, 8 (4).
37. Jue Hou, Huacheng Zhang. Advanced Methods for Ion Selectivity Measurement in Nanofluidic Devices. Advanced Materials Technologies 2023, 8 (9).
38. Pengyang Xin, Linqi Xu, Wenpei Dong, Linlin Mao, Jingjing Guo, Jingjing Bi, Shouwei Zhang, Yan Pei, Chang‐Po Chen. Synthetic K + Channels Constructed by Rebuilding the Core Modules of Natural K + Channels in an Artificial System. Angewandte Chemie 2023, 135 (8).
39. Pengyang Xin, Linqi Xu, Wenpei Dong, Linlin Mao, Jingjing Guo, Jingjing Bi, Shouwei Zhang, Yan Pei, Chang‐Po Chen. Synthetic K + Channels Constructed by Rebuilding the Core Modules of Natural K + Channels in an Artificial System. Angewandte Chemie International Edition 2023, 62 (8).
40. Weiwen Xin, Lei Jiang, Liping Wen. Engineering Bio‐inspired Self‐assembled Nanochannels for Smart Ion Transport. Angewandte Chemie 2022, 134 (40).