Kidney water channel research reagent

function

Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Could also be permeable to glycerol (By similarity).

Gene Ontology

Gene Ontology (GO) annotations organized by slimming set.

Slimming set:

Cell color indicative of number of GO terms

Access the complete set of GO annotations on QuickGO

Keywords

• Biological process

Enzyme and pathway databases

• • R-BTA-432040 Vasopressin regulates renal water homeostasis via Aquaporins
  • R-BTA-432047 Passive transport by Aquaporins

Protein names

• Recommended name

Aquaporin-2

• Short name

AQP-2

• Alternative names
  • ADH water channel
  • Aquaporin-CD (AQP-CD)
  • Collecting duct water channel protein
  • WCH-CD
  • Water channel protein for renal collecting duct

Gene names

• • Name

AQP2

Organism names

• Taxonomic identifier
• Organism
• Strain
  • Hereford

Taxonomic lineage

Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Laurasiatheria > Artiodactyla > Ruminantia > Pecora > Bovidae > Bovinae > Bos

Accessions

• Primary accession

P79099

• Secondary accessions
  • A7MBE5

Proteomes

• • Identifier
  • Component

Chromosome 5

Organism-specific databases

Note: Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.

Features

Showing features for topological domain, transmembrane, intramembrane.

Keywords

• Cellular component

Gene expression databases

• • ENSBTAG00000008374 Expressed in adult mammalian kidney and 17 other cell types or tissues

Subunit

Homotetramer.

Protein-protein interaction databases

• • P79099 119 interactors

Features

Showing features for motif, region, compositional bias.

Domain

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Sequence similarities

Keywords

• Domain

Family and domain databases

• View the Phylogenomic databases for this entry within the Similar Proteins section.
• View all family and domain features for this entry's canonical sequence in the UniParc Feature Viewer.

• • cd00333 MIP 1 hit

• • 1.20.1080.10:FF:000003 Lens fiber major intrinsic 1 hit

• • 1.20.1080.10 Glycerol uptake facilitator protein 1 hit

• • TIGR00861 MIP 1 hit

• • PTHR19139 AQUAPORIN TRANSPORTER 1 hit
  • PTHR19139:SF45 AQUAPORIN-2 1 hit

• • PR02014 AQUAPORIN2
  • PR00783 MINTRINSICP

• • SSF81338 Aquaporin-like 1 hit

Sequence status

Complete

Length

271

Mass (Da)

28,890

Last updated

2007-11-13 v2

MD5 Checksum

27CC8F41DCFAE26F594581AC6890CB0F

MWELRSIAFSRAVLAEFLATLLFVFFGLGSALNWPQALPSVLQIAMAFGLAIGTLVQALGHVSGAHINPAVTVACLVGCHVSFLRAVFYVAAQLLGAVAGAALLHEITPPAIRGDLAVNALNNNSTAGQAVTVELFLTLQLVLCIFASTDERRGDNVGTPALSIGFSVALGHLLGIHYTGCSMNPARSLAPAIVTGKFDDHWVFWIGPLVGAIVASLLYNYVLFPPAKSLSERLAVLKGLEPDTDWEEREVRRRQSVELHSPQSLPRGSKA

Features

Showing features for compositional bias.

Keywords

• Technical term

Sequence databases

Genome annotation databases

UniRef clusters

Orthologs & paralogs

Phylogenomic databases

• • KOG0223 Eukaryota

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.