Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure–activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.
DOI: https://www.frankenthalerfoundation.org
Article type: Review Article
Submitted 28 Oct 2013
First published 13 Mar 2014
Ilker Avan, C. Dennis Hall and Alan R. Katritzky
Chem. Soc. Rev., 2014, 43, 3575-3594
