Lixisenatide

[D-TRP32]Neuropeptide Y: A Competitive Antagonist of NPY in Rat Hypothalamus

yakuchinone a cas no 78954 23 1 molecular research

Article March 1, 1994

[D-TRP32]Neuropeptide Y: A Competitive Antagonist of NPY in Rat Hypothalamus

Authors

A. Balasubramaniam
S. Sheriff
M. E. Johnson
M. Prabhakaran
Y. Huang
J. E. Fischer
W. T. Chance

Journal of Medicinal Chemistry

Cite this: J. Med. Chem. 1994, 37, 6

Published March 1, 1994

research-article

Article Views

124

Altmetric

Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.

Citations are the number of other articles citing this article, calculated by Crossref and updated daily.

The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online.

ACS Publications

Note: In lieu of an abstract, this is the article's first page.

Cited By

This article is cited by 61 publications.

Number	Citation Details
1.	Xiaozhe Zhang, Filomena Petruzziello, Fabio Zani, Laetitia Fouillen, Per E. Andren, Giovanni Solinas, and Gregor Rainer . High Identification Rates of Endogenous Neuropeptides from Mouse Brain. Journal of Proteome Research 2012, 11 (5) , 2819-2827.
2.	Mendel Friedman. Chemistry, Nutrition, and Microbiology of d-Amino Acids. Journal of Agricultural and Food Chemistry 1999, 47 (9) , 3457-3479.
3.	A. Balasubramaniam, M. Ujhelyi, M. Borchers, Y. Huang, W. Zhai, Y. Zhou, M. Johnson, S. Sheriff, and J. E. Fischer. Antagonistic Properties of Centrally Truncated Analogs of [d-Trp32]NPY. Journal of Medicinal Chemistry 1996, 39 (5) , 1142-1147.
4.	A. Balasubramaniam, W. Zhai, S. Sheriff, Z. Tao, W. T. Chance, J. E. Fischer, P. Eden, and J. Taylor. Bis(31/31‘){[Cys31,Trp32,Nva34]NPY- (31−36)}: A Specific NPY Y-1 Receptor Antagonist. Journal of Medicinal Chemistry 1996, 39 (4) , 811-813.
5.	Ernie Yulyaningsih, Lei Zhang, Herbert Herzog, Amanda Sainsbury. NPY receptors as potential targets for anti‐obesity drug development. British Journal of Pharmacology 2011, 163 (6) , 1170-1202.
6.	Michael Haack, Annette G. Beck-Sickinger. Multiple Peptide Synthesis to Identify Bioactive Hormone Structures. 2007, 243-288.
7.	Bernard Beck. Hypothalamic Neuropeptides and Feeding Regulation. 2007, 67-98.
8.	Marcio C Mancini, Alfredo Halpern. Investigational therapies in the treatment of obesity. Expert Opinion on Investigational Drugs 2006, 15 (8) , 897-915.
9.	Magnus M. Berglund, Philip A. Hipskind, Donald R. Gehlert. Function, distribution and molecular pharmacology of NPY-family receptors. 2005, 29-62.
10.	Volker Schusdziarra, Jens P. Zimmermann, Rafael R. Schick. Importance of Orexigenic Counter‐Regulation for Multiple Targeted Feeding Inhibition. Obesity Research 2004, 12 (4) , 627-632.
11.	K. Mörl, A. G. Beck-Sickinger. Structure-Activity Relationship of Peptide-Derived Ligands at NPY Receptors. 2004, 479-503.
12.	Q Lin, X Zou, Y Ren, J Wang, L Fang, W.D Willis. Involvement of peripheral neuropeptide y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin. Neuroscience 2004, 123 (2) , 337-347.
13.	Paula D. Raposinho, Thierry Pedrazzini, Richard B. White, Richard D. Palmiter, Michel L. Aubert. Chronic Neuropeptide Y Infusion into the Lateral Ventricle Induces Sustained Feeding and Obesity in Mice Lacking Either Npy1r or Npy5r Expression. Endocrinology 2004, 145 (1) , 304-310.
14.	Magnus M. Berglund, Philip A. Hipskind, Donald R. Gehlert. Recent Developments in Our Understanding of the Physiological Role of PP-Fold Peptide Receptor Subtypes. Experimental Biology and Medicine 2003, 228 (3) , 217-244.
15.	Ambikaipakan Balasubramaniam, Sulaiman Sheriff, Weixu Zhai, William T Chance. Bis(31/31′){[Cys31, Nva34]NPY(27–36)-NH2}: a neuropeptide Y (NPY) Y5 receptor selective agonist with a latent stimulatory effect on food intake in rats. Peptides 2002, 23 (8) , 1485-1490.
16.	Ants Kask, Jaanus Harro, Stephan von Hörsten, John P. Redrobe, Yvan Dumont, Rémi Quirion. The neurocircuitry and receptor subtypes mediating anxiolytic-like effects of neuropeptide Y. Neuroscience & Biobehavioral Reviews 2002, 26 (3) , 259-283.
17.	Z. Tao, F. Peng, S. Sheriff, P. Eden, J. Taylor, W. T. Chance, A. Balasubramaniam. Development of feeding and Y-1 NPY receptor antagonists. 2002, 578-579.
18.	Külliki Saar, Riina Mahlapuu, Erki Laidmäe, Andres Valkna, Ulrika Kahl, Ello Karelson, Ülo Langel. Characterisation of a new chimeric ligand for galanin receptors: galanin(1–13)-[d-Trp32]-neuropeptide Y(25–36)amide. Regulatory Peptides 2001, 102 (1) , 15-19.
19.	Deborra Mullins, Dean Kirby, Joyce Hwa, Mario Guzzi, Jean Rivier, Eric Parker. Identification of Potent and Selective Neuropeptide Y Y1 Receptor Agonists with Orexigenic Activity in Vivo. Molecular Pharmacology 2001, 60 (3) , 534-540.
20.	M.M. Berglund, K. Saar, I. Lundell, Ü. Langel, D. Larhammar. Binding of chimeric npy/galanin peptides M32 and M242 to cloned neuropeptide Y receptor subtypes Y1, Y2, Y4, and Y5. Neuropeptides 2001, 35 (3-4) , 148-153.
21.	M. Jászberényi, E. Bujdosó, G. Telegdy. The Role of Neuropeptide Y in Orexin‐Induced Hypothalamic‐Pituitary‐Adrenal Activation. Journal of Neuroendocrinology 2001, 13 (5) , 438-441.
22.	Chiara Cabrele, Michael Langer, Reto Bader, Heike A. Wieland, Henri N. Doods, Oliver Zerbe, Annette G. Beck-Sickinger. The First Selective Agonist for the Neuropeptide YY5Receptor Increases Food Intake in Rats. Journal of Biological Chemistry 2000, 275 (46) , 36043-36048.
23.	Eric M Parker, Ambikaipakan Balasubramaniam, Mario Guzzi, Deborra E Mullins, Brian G Salisbury, Sulaiman Sheriff, Melanie B Witten, Joyce J Hwa. [D-Trp34] neuropeptide Y is a potent and selective neuropeptide Y Y5 receptor agonist with dramatic effects on food intake. Peptides 2000, 21 (3) , 393-399.
24.	Y. Dumont, D. Jacques, J.-A. St-Pierre, Y. Tong, R. Parker, H. Herzog, R. Quirion. Chapter IX Neuropeptide Y, peptide YY and pancreatic polypeptide receptor proteins and mRNAs in mammalian brains. 2000, 375-475.
25.	Parul Sharma, Ann-Kristin Arvidsson, Amanda Wraith, Annette G. Beck-Sickinger, Ann-Cathrine Jönsson-Rylander, Dan Larhammar. Characterization of the Cloned Atlantic Cod Neuropeptide Y-Yb Receptor: Peptide-Binding Requirements Distinct from Known Mammalian Y Receptors. General and Comparative Endocrinology 1999, 115 (3) , 422-428.
26.	Paula D. Raposinho, Pierre Broqua, Dominique D. Pierroz, Amanda Hayward, Yvan Dumont, Remi Quirion, Jean-Louis Junien, Michel L. Aubert. Evidence That the Inhibition of Luteinizing Hormone Secretion Exerted by Central Administration of Neuropeptide Y (NPY) in the Rat Is Predominantly Mediated by the NPY-Y5 Receptor Subtype1. Endocrinology 1999, 140 (9) , 4046-4055.
27.	Paula Starbäck, Ingrid Lundell, Robert Fredriksson, Magnus M Berglund, Yi-Lin Yan, Amanda Wraith, Charlotte Söderberg, John H Postlethwait, Dan Larhammar. Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish: the zYa receptor. Molecular Brain Research 1999, 70 (2) , 242-252.
28.	J.Mark VanNess, Jamie E DeMaria, J.Michael Overton. Increased NPY activity in the PVN contributes to food-restriction induced reductions in blood pressure in aortic coarctation hypertensive rats. Brain Research 1999, 821 (2) , 263-269.
29.	Michael A Statnick, Douglas A Schober, Susan Gackenheimer, Dwayne Johnson, Lisa Beavers, Nancy G Mayne, J.Paul Burnett, Robert Gadski, Donald R Gehlert. Characterization of the neuropeptide Y5 receptor in the human hypothalamus: a lack of correlation between Y5 mRNA levels and binding sites. Brain Research 1998, 810 (1-2) , 16-26.
30.	Michel Félétou, Marianne Rodriguez, Philippe Beauverger, Martine Germain, Jerôme Imbert, Sandra Dromaint, Christelle Macia, Aline Bourrienne, Jean-Michel Henlin, Jean-Paul Nicolas, Jean A Boutin, Jean-Pierre Galizzi, Jean-Luc Fauchère, Emmanuel Canet, Jacques Duhault. NPY receptor subtypes involved in the contraction of the proximal colon of the rat. Regulatory Peptides 1998, 75-76, 221-229.
31.	Ants Kask, Lembit Rägo, Jaanus Harro. Anxiogenic-like effect of the NPY Y1 receptor antagonist BIBP3226 administered into the dorsal periaqueductal gray matter in rats. Regulatory Peptides 1998, 75-76, 255-262.
32.	Andrea C Haynes, Jonathan R.S Arch, Shelagh Wilson, Steven Mc Clue, Robin E Buckingham. Characterisation of the neuropeptide Y receptor that mediates feeding in the rat: a role for the Y5 receptor?. Regulatory Peptides 1998, 75-76, 355-361.
33.	P Wyss, A Stricker-Krongrad, L Brunner, J Miller, A Crossthwaite, S Whitebread, L Criscione. The pharmacology of neuropeptide Y (NPY) receptor-mediated feeding in rats characterizes better Y5 than Y1, but not Y2 or Y4 subtypes. Regulatory Peptides 1998, 75-76, 363-371.
34.	D.G.A Morgan, C.J Small, S Abusnana, M Turton, I Gunn, M Heath, M Rossi, A.P Goldstone, D O'Shea, K Meeran, M Ghatei, D.M Smith, S Bloom. The NPY Y1 receptor antagonist BIBP 3226 blocks NPY induced feeding via a non-specific mechanism. Regulatory Peptides 1998, 75-76, 377-382.
35.	William T. Chance, Zhiyong Tao, Sulaiman Sheriff, Ambikaipakan Balasubramaniam. WRYamide, A NPY-based tripeptide that antagonizes feeding in rats. Brain Research 1998, 803 (1-2) , 39-43.
36.	Ants Kask, Lembit Rägo, Jaanus Harro. Evidence for involvement of neuropeptide Y receptors in the regulation of food intake: studies with Y 1 ‐selective antagonist BIBP3226. British