Helen Frankenthaler Foundation

Membrane targeting efficacy

cGMP Therapeutic Peptides Manufacturing | Esco Aster

Therapeutic Peptides

We understand that peptide development is filled with challenges. Due to hydrophilicity, peptides exhibit limited ability to cross physiological barriers and are confronted with efficient hepatic and renal clearance. Also, once inside the systemic circulation, peptides typically have rather short half lives due to aggressive degradation by multiple digestive proteases. These aspects have led to difficult administration routes which resulted to low patient compliance

Synthetic Services

We are capable of synthesizing broad range of therapeutic peptides / proteins through:

  • A novel continuous flow approach with the latest technology
  • Conventional Solid Phase Peptide
  • Synthesis/Liquid Phase Peptide Synthesis (SPPS/LPPS)
  • Combo Technology
  • Fermentation
  • Recombinant DNA methodology

Comprehensive Peptide Modifications

Through our in-house technologies, we have the ability to increase their half-lives through:

  • Polyethylene Glycol (PEG) Modification
    • Linkers
    • Spacers
  • N-terminal and Side-chain Modification
    • PEGylation
    • Acetylation (lipopeptides)
    • Formylation
  • Peptide Stapling
    • Ring Closing Metathesis (RCM)
    • Thioether Formation
  • Peptide Macrolyzation

A World of Possibilities with Peptides

Esco Aster manufactures the highest quality peptide products and are widely used in the following applications:

Esco Aster Pte Ltd is a cGMP CRDMO operating as an independent subsidiary of Esco Lifesciences Group. We provide process development (PD) and contract manufacturing (from upstream to downstream, formulation and filling), consultation, and clinical research services bridging the translation gap from bench to bedside.

Esco Aster Pte. Ltd.

Address: #02-01, Blk 67 Ayer Rajah Crescent, Singapore 139950,

Phone: +65 6251 9361

Email: admin@frankenthalerfoundation.org

Esco AsterTide PD-Phase 2 CTM (Cells/Viruses/EVs)

Address: #02-04 Blk 67 Ayer Rajah Crescent Singapore 139950

Phone: +65 6251 9361

Email: admin@frankenthalerfoundation.org

Esco AsterMavors Cellular Agriculture and Complementary Proteins (Food)

Address: #03-20 Blk 71 Ayer Rajah Crescent Singapore 139951

Phone: +65 6251 9361

Email: admin@frankenthalerfoundation.org