Catalog No. TP1004 Cas No. 17908-57-5
Alias β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human
beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor).
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Description beta-MSH, human is an endogenous peptide hormone and neurotransmitter produced by pro-opiomelanocortin (POMC), and is also an agonist of MC4-R (melanocortin 4 receptor). In vitro In human THP-1 monocytic cells, beta-MSH (0.1–100 nM) suppressed lipopolysaccharide (LPS, 10 ng/mL)-induced TNF-α production in a concentration-dependent manner, with maximal inhibition observed at 1–10 nM. beta-MSH did not significantly alter IL-10 expression but reduced proinflammatory cytokine production via activation of melanocortin receptors, particularly MC1R and MC3R. In vivo In mouse models, intraperitoneal injection of beta-MSH (0.5 mg/kg) significantly reduced plasma TNF-α levels induced by LPS (0.5 mg/kg) and attenuated inflammatory responses. Synonyms β-MSH, human, β-Melanocyte Stimulating Hormone (MSH), human
Molecular Weight 2660.92 Formula C 118 H 174 N 34 O 35 S Cas No.17908-57-5 Smiles C([C@H](NC([C@@H](NC([C@H](CC1=CC=CC=C1)NC([C@H](CC2=CN=CN2)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]3N(C(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)CCC(O)=O)=O)CCCCN)=O)CCCCN)=O)CC(O)=O)=O)CCC(O)=O)=O)=O)CCC3)CC4=CC=C(O)C=C4)=O)CCCNC(=N)N)=O)CCSC)=O)CCC(O)=O)=O)=O)=O)CCCNC(=N)N)=O)C(NCC(N[C@H](C(=O)N5[C@H](C(=O)N6[C@H](C(N[C@H](C(N[C@@H](CC(O)=O)C(O)=O)=O)CCCCN)=O)CCC6)CCC5)CO)=O)=O)C=7C=8C(NC7)=CC=CC8 Relative Density.no data available Sequence Ala-Glu-Lys-Lys-Asp-Glu-Gly-Pro-Tyr-Arg-Met-Glu-His-Phe-Arg-Trp-Gly-Ser-Pro-Pro-Lys-Asp Sequence Short AEKKDEGPYRMEHFRWGSPPKD
Storage keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. Solubility Information H2O: 50 mg/mL (18.79 mM) Solution Preparation Table H2O
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method: For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH 2 O , the resulting working solution concentration would be 2 mg/mL. Stock Solution Preparation: Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding. Preparation of the In Vivo Formulation: 1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear. 2) Add 50 μL Tween 80 and mix well until fully clarified. 3) Add 450 μL Saline, PBS or ddH 2 O and mix thoroughly until a homogeneous solution is obtained. This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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