Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS 1 (high affinity) and NTS 2 (low affinity) and the single transmembrane receptor NTS 3 (Sortilin 1).
Neurotensin (NT) is a brain and gastrointestinal peptide that acts on three subtypes of neurotensin receptors: the G-protein-coupled receptors NTS 1 (high affinity) and NTS 2 (low affinity) and the single transmembrane receptor NTS 3 (Sortilin 1). These receptors have many central and peripheral actions including modulation of dopaminergic transmission in nigro-striatal and mesocorticolimbic pathways, modulation of the digestive tract and hypothermic and analgesic effects.
NTS 1 is distributed widely throughout the brain and gastrointestinal tract, whilst NTS 2 is confined to areas of the brain involved in the descending control of nociception, including the periaqueductal gray and dorsal raphe. The human genes encoding NTS 1 and NTS 2 receptors are located on chromosomes 20q13 and 2p25.1 respectively.
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Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
8876 | Rhobo6 ECM Dye Fluorogenic probe for labeling the extracellular matrix (ECM) in live tissues
8910 | NAIA
