Helen Frankenthaler Foundation

Neurokinin B supplier

Target: Neuromedin-U receptor 2 (CHEMBL1075144)

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Target: Neuromedin-U receptor 2 (CHEMBL1075144)

ID: CHEMBL1075144

Type

SINGLE PROTEIN

Preferred Name

Neuromedin-U receptor 2

Synonyms

  • G-protein coupled receptor FM-4
  • G-protein coupled receptor TGR-1
  • Neuromedin-U receptor 2
  • NMU2R
  • NMU-R2

Organism

Homo sapiens

Species Group

No

Protein Target Classification

1.

DescriptionRelationshipAccession
Neuromedin-U receptor 2SINGLE PROTEINQ9GZQ4

Associated Bioactivities

Total: 393

  • EC50
  • Activity
  • Emax
  • IC50
  • Ki
  • Intrinsic activity
  • Kb
  • Kd
  • Mean fold stimulation
  • RLU

Associated Assays

Total: 46

  • F - Functional
  • B - Binding
  • A - ADME

Ligand Efficiencies for Target CHEMBL1075144 (Neuromedin-U receptor 2)

Showing 9 data points.

The Ligand Efficiency chart plots Binding Efficiency Index (BEI) against Surface Efficiency Index (SEI), where:

  • SEI = (-log10(Standard Value*10^-9))*100/PSA
  • BEI = (-log10(Standard Value*10^-9))*1000/MWT
Parent Molecular Weight
ALogP
Polar Surface Area
Histogram Settings

Interval Size (309.53)

Total: 236

Cellular Component

  • GO:0005886 (plasma membrane)
  • GO:0016020 (membrane)

Molecular Function

  • GO:0001607 (neuromedin U receptor activity)
  • GO:0004930 (G protein-coupled receptor activity)
  • GO:0005229 (intracellularly calcium-gated chloride channel activity)
  • GO:0005515 (protein binding)
  • GO:0005525 (GTP binding)
  • GO:0008188 (neuropeptide receptor activity)
  • GO:0042924 (neuromedin U binding)

Biological Process

  • GO:0002023 (reduction of food intake in response to dietary excess)
  • GO:0006940 (regulation of smooth muscle contraction)
  • GO:0007186 (G protein-coupled receptor signaling pathway)
  • GO:0007200 (phospholipase C-activating G protein-coupled receptor signaling pathway)
  • GO:0007218 (neuropeptide signaling pathway)
  • GO:0007267 (cell-cell signaling)
  • GO:0007417 (central nervous system development)
  • GO:0007625 (grooming behavior)
  • GO:0007631 (feeding behavior)
  • GO:0048265 (response to pain)
  • GO:0050482 (arachidonate secretion)
  • GO:0050850 (positive regulation of calcium-mediated signaling)
  • GO:1902476 (chloride transmembrane transport)

InterPro

  • IPR000276 (GPCR_Rhodpsn)
  • IPR005390 (NeuromedU_rcpt)
  • IPR005392 (NeuromedU_rcpt_2)
  • IPR017452 (GPCR_Rhodpsn_7TM)
  • IPR045561 (NMU-R2_C)

Pfam

  • PF00001 (7tm_1)
  • PF19285 (NmU-R2_C_term)