A xanthone with diverse biological activities
Garcinone D is a xanthone that has been found in G. mangostana and has diverse biological activities. It increases proliferation of C17.2 neural progenitor cells (NPCs) when used at a concentration of 5 µM, an effect that can be reduced by inhibition of the antioxidative transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). It increases phosphorylation of STAT3 and cyclin D1 and the protein levels of Nrf2 and heme oxygenase-1 (HO-1) in a concentration-dependent manner.
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