The neurokinin 3 (NK 3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK 1 and NK 2 receptors. The NK 3 receptor is predominantly expressed in the CNS (including the hippocampus, hypothalamus and substantia nigra).
The neurokinin 3 (NK 3) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK 1 and NK 2 receptors. The NK 3 receptor is predominantly expressed in the CNS (hippocampus, hypothalamus, substantia nigra, dorsal horn of the spinal cord) with limited expression in the periphery.
NK 3 receptors are thought to mediate afferent neuron transmission and intestinal motility and secretion. The receptor displays greater potency for the endogenous agonist neurokinin B than neurokinin A and substance P (NKB > NKA > SP). The human gene encoding the NK 3 receptor has been localized on chromosome 4 (4q25).
Tocris offers the following scientific literature for NK 3 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
8876 | Rhobo6 ECM Dye Fluorogenic probe for labeling the extracellular matrix (ECM) in live tissues
8910 | NAIA Broad spectrum cysteine reactive probe; suitable for live-cell applications
8913 | NVP-TNKS656 Tankyrase (AKA PARP5) inhibitor; used to generate neurons from epiblast stem cells
8952 | VVD 844 Potent covalent inhibitor of the RAS domain of the PI3K/p110α interaction
8993 | CX-4945 Potent and selective CK2α and CK2α' inhibitor
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