Helen Frankenthaler Foundation

Opioid hyperalgesia research peptide

Dermorphin (acetate)

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Dermorphin (acetate)

An opioid peptide

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Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

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Biochemicals

Peptides

Small Molecule Modulators

Receptor Pharmacology

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Neuroscience

Pain Research

Item No. 31607

Technical Information
Formal Name(S)-1-(L-tyrosyl-D-alanyl-L-phenyl alanylglycyl-L-tyrosyl)-N-((S)-1-amino-3-hydroxy-1-oxopropan-2-yl)pyrrolidine-2-carboxamide, acetate
Molecular FormulaC 40 H 50 N 8 O 10 • XC 2 H 4 O 2
Formula Weight802.9
Purity≥95%
FormulationA crystalline solid
SolubilityDMF: 30 mg/ml DMSO: 30 mg/ml Ethanol: 30 mg/ml PBS (pH 7.2): 10 mg/ml
λ max224 nm
SMILESOC(C=C1)=CC=C1C[C@H](NC(CNC([C@@H](NC([C@@H](C)NC([C@@H](N)CC2=CC=C(C=C2)O)=O)=O)CC3=CC=CC=C3)=O)=O)C(N4[C@H](C(N[C@@H](CO)C(N)=O)=O)CCC4)=O.CC(O)=O
InChi CodeInChI=1S/C40H50N8O10.C2H4O2/c1-23(44-37(55)29(41)18-25-9-13-27(50)14-10-25)36(54)46-30(19-24-6-3-2-4-7-24)38(56)43-21-34(52)45-31(20-26-11-15-28(51)16-12-26)40(58)48-17-5-8-33(48)39(57)47-32(22-49)35(42)53;1-2(3)4/h2-4,6-7,9-16,23,29-33,49-51H,5,8,17-22,41H2,1H3,(H2,42,53)(H,43,56)(H,44,55)(H,45,52)(H,46,54)(H,47,57);1H3,(H,3,4)/t23-,29+,30+,31+,32+,33+;/m1./s1
InChi KeyUQNSJPMLMSSQJY-YYEHHWDVSA-N
Shipping & Storage Information
Storage-20°C
ShippingRoom temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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  • 1 mg $36 In stock
  • 5 mg $153 In stock
  • 10 mg $268 In stock
  • 25 mg $587 In stock
  • BULK & CUSTOM
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Product Description

Dermorphin is an opioid peptide originally isolated from the skin of South American frogs (Ph. sauvagei). It binds to μ-opioid receptors (K i = 0.54 nM) and is selective for μ- over δ-opioid receptors in radioligand binding assays (K i = 929 nM). In vivo, dermorphin (1.9 µmol/kg, i.p.) inhibits noxious stimuli-induced neuronal firing in the nucleus lateralis anterior and ventrobasal complex in rats. It inhibits the electrical stimulation-induced C fiber response in rat dorsal horn nociceptive neurons. Dermorphin (10-120 pmol/animal, i.c.v.) delays gastric emptying, inhibits gastric acid secretion, and slows colonic motility in pylorus-ligated rats.

WARNING This product is not for human or veterinary use.

References & Product Citations