Organic synthesis building block

Chemical Synthesis

Our team of synthetic organic and medicinal chemists brings decades of industry experience to perform complex, multi-step organic syntheses. Supported by our Medicinal Chemistry & Structure-Based Drug Design and GMP & Process Development Services, our team of highly skilled organic chemists possesses broad synthetic proficiencies beyond our core expertise in lipid, bioconjugate, and stable isotopic labeling chemistry.

Synthesis, Purification, and Characterization

• Complex fatty acid metabolites, glycerophospholipids, sphingolipids, and sterols
• Small molecule, drug-like heterocyclic compounds
• Classic and emerging drugs of abuse including PEDs, LSD, amphetamines, benzodiazepines, synthetic cannabinoids, opioids, and more
• Stable isotope-labeled target standards

Analytical Standards Development

• Analytical Standards
• Reference Materials
• Certified Reference Materials

Small Molecule Analog Synthesis/SAR, Parallel Medicinal Chemistry, and Compound Library Generation

• Hit-to-Lead: design, synthesis, and screening
• Lead optimization and scale-up

Specialized Syntheses

• Bioconjugation
• Fluorescent dye design, development, and synthesis
• Selective, stable isotopic labeling
• Natural Product Chemistry: extraction from biological sources and total synthesis

GMP and Process Development

• Chemical route exploration, development, and optimization
• Pre-clinical/clinical API synthesis and method validation
• Commercial GMP-API manufacturing

Lipid Nanoparticle (LNP) Development

• Custom lipid synthesis
• LNP formulation and characterization
• LNP analysis and screening