oxandrolone pubmed

oxandrolone

camellianin a molecular research

oxandrolone

Description

Synonyms: oxandrolone, anavar, lonavar, oxandren, oxandrin, vasorome

A synthetic hormone with anabolic and androgenic properties.

Molecular weight: 306.45
Formula: C19H30O3
CLOGP: 2.96
LIPINSKI: 0
HAC: 3
HDO: 1
TPSA: 46.53
ALOGS: -4.34
ROTB: 0
Status: OFM
Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage

None

ADMET properties

Property	Value	Reference
BA (Bioavailability)	97 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Hosey CM, Chan R, Benet LZ
S (Water solubility)	0.01 mg/mL	Bocci G, Oprea TI, Benet LZ

Approvals

Date	Agency	Company	Orphan
July 21, 1964	FDA	CREALTA PHARMS LLC	-

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hereditary angioedema	40.24	36.04	8	158	7554	63481302

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Testicular atrophy	51.86	41.76	8	262	584	34956077
Muscle mass	50.08	41.76	7	263	257	34956404

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Testicular atrophy	58.87	34.86	8	399	363	79743618
Muscle mass	49.00	34.86	7	400	457	79743524

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action

Source	Code	Description
ATC	A14AA08	ALIMENTARY TRACT AND METABOLISM ANABOLIC AGENTS FOR SYSTEMIC USE ANABOLIC STEROIDS Androstan derivatives
CHEBI has role	CHEBI:50113	androgene
MeSH PA	D045930	Anabolic Agents
MeSH PA	D000728	Androgens
MeSH PA	D006728	Hormones

Drug Use

Disease	Relation	SNOMED_ID	DOID
Catabolic Process	indication
Turner syndrome	off-label use	38804009	DOID:3491
Hypercholesterolemia	contraindication	13644009
Nephrotic syndrome	contraindication	52254009	DOID:1184
Peliosis hepatis	contraindication	58008004	DOID:914
Blood coagulation disorder	contraindication	64779008	DOID:1247
Hypercalcemia	contraindication	66931009	DOID:12678
Arteriosclerotic vascular disease	contraindication	72092001
Heart failure	contraindication	84114007	DOID:6000
Kidney disease	contraindication	90708001	DOID:557

Veterinary Drug Use

None

Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Androgen receptor	Nuclear hormone receptor	P10275	ANDR_HUMAN	AGONIST	IC50	9.09	-	CHEMBL	CHEMBL

External reference

ID	Source
001258	NDDF
126128007	SNOMEDCT_US
1325	INN_ID
224933	RXNORM
2679000	SNOMEDCT_US
4018126	VUID
4018126	VANDF
4491	MMSL
5209	MMSL
5878	PUBCHEM_CID

Pharmaceutical products

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	0245-0271	TABLET	2.50 mg	ORAL	ANDA	25 sections
oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	0245-0272	TABLET	10 mg	ORAL	ANDA	24 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	49884-301	TABLET	2.50 mg	ORAL	ANDA	20 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	49884-301	TABLET	2.50 mg	ORAL	ANDA	20 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	49884-301	TABLET	2.50 mg	ORAL	ANDA	20 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	49884-302	TABLET	10 mg	ORAL	ANDA	20 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	49884-302	TABLET	10 mg	ORAL	ANDA	20 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	49884-302	TABLET	10 mg	ORAL	ANDA	20 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	63629-7603	TABLET	2.50 mg	ORAL	ANDA	20 sections
Oxandrolone	HUMAN PRESCRIPTION DRUG LABEL	1	63629-7603	TABLET	2.50 mg	ORAL	ANDA	20 sections