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Calmodulin-Dependent Protein Kinase II(290-309) acetate

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Calmodulin-Dependent Protein Kinase II(290-309) acetate

Catalog No. GC61521

Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II.

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Description of Calmodulin-Dependent Protein Kinase II(290-309) acetate

Calmodulin-Dependent Protein Kinase II (290-309) acetate is a potent CaMK antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase II[1].

Peptide 290 to 309 is found to be a potent calmodulin antagonist with an IC50 of 52 nM for inhibition of Ca2+/calmodulin-dependent protein kinase. Neither truncation from the amino terminus (peptide 296-309) nor extension in the carboxyl-terminal direction (peptide 294-319) markedly affects calmodulin binding, whereas shortening the peptide from the carboxyl terminus (peptide 290-302) or from both ends (peptide 295-304) results in the elimination of this activity[1].

[1]. Payne ME, et al. Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains. J Biol Chem. 1988 May 25;263(15):7190-5.

Chemical Properties of Calmodulin-Dependent Protein Kinase II(290-309) acetate

PropertyValue
Cas No.SDF
FormulaC 105 H 189 N 31 O 26 S
M.Wt2333.88
Solubility
StorageStore at -20°C
General tipsPlease select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping ConditionEvaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
Complete Stock Solution Preparation Table of Calmodulin-Dependent Protein Kinase II(290-309) acetate

Prepare stock solution

Concentration1 mg5 mg10 mg
1 mM428.5 μL2.1424 mL4.2847 mL
5 mM85.7 μL428.5 μL856.9 μL
10 mM42.8 μL214.2 μL428.5 μL
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