PAR-4 Agonist Peptide, amide (PAR-4-AP, AY-NH2) is a agonist of proteinase-activated receptor-4 (PAR-4) that provides antinociceptive effects in stress- and inflammation-induced hyperalgesia. It reduces visceral pain by activating PAR-4 receptors on colonic nerve terminals.
Molecular Weight: 680.80
Cat.No.: E7144 Product Name: PAR-4 Agonist Peptide, amide
Select batch Batch:Purity: 99.78%
In vitro batch selection In vitro
Batch:DMSO : 100 mg/mL (146.88 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) Water : 100 mg/mL Ethanol : 25 mg/mL DMSO : 100 mg/mL (146.88 mM) (Moisture-contaminated DMSO may reduce solubility. Use fresh, anhydrous DMSO.) Water : 100 mg/mL Ethanol : 100 mg/mL
Dilution Calculator Molecular Weight Calculator
In vivo batch selection In vivo
Batch: Oral Administration Homogeneous suspension CMC-NA≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml. Homogeneous suspension CMC-NA≥5mg/ml Taking the 1 mL working solution as an example, add 5 mg of this product to 1 ml of CMC-Na solution, mix evenly to obtain a homogeneous suspension with a final concentration of 5 mg/ml.
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment) Dosage: mg/kg Average weight of animals: g Dosing volume per animal: μL Number of animals:
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.) DMSO percentage % DMSO + Second solvent percentage % + Tween 80 percentage % Tween 80 + Water (ddH₂O) percentage % ddH 2 O DMSO percentage % DMSO + Corn oil percentage % Calculate
Calculation results: Working concentration: mg/ml; Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. ) Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL PEG300, mix and clarify, next add μL Tween 80, mix and clarify, next add μL ddH 2 O, mix and clarify. Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify. Note: 1. Please make sure the liquid is clear before adding the next solvent. 2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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