Peptide Blends

Peptide Synthesis Modifications

N-Terminal Modification

• Acetylation {Ac}
• Biotin
• Biotin-Ahx
• 5-FAM
• 5-FAM-Ahx
• 6-FAM
• FITC-Ahx
• 5-TAMRA
• Dansyl
• Fmoc
• MCA
• Myristoyl (Myr)
• Palmitoyl
• Rhodamine B
• Abz
• Benzoyl {Bz}
• Br-Ac
• Cl-Ac
• CBZ
• Cy3
• Cy5
• DABCYL
• Dansyl-Ahx
• Decanoic acid
• Formylation {For}
• Hexanoic acid
• Lauric acid
• Octanoic acid
• Stearic acid
• Succinylation {Suc}
• Bz(4-F)
• Bz(4-NO2)
• Pyr
• D-Pyr
• {LA}, Lipoic acid
• Mpa
• Mpr
• 3-Maleimide
• 6-Maleimide

N-Terminal Modification - Conjugation

• KLH conjugation on N-terminal (-NH2)
• BSA conjugation on N-terminal (-NH2)
• OVA conjugation on N-terminal (-NH2)

N-Terminal Modification - Fatylation

• 2-I-Ac
• OH-Ac
• But
• MeOSuc
• Iba
• 5-heptenoic acid
• 5-Hexynoic acid
• heptanedioic acid
• Sebacic Acid
• Pal
• Octanedioic acid
• Oleic Acid

C-Terminal Modification

• Amidation {NH2}
• AMC (7-Amino-4-Methylcoumarin)
• Cysteamide {Cya}
• p-Nitroanilide
• Ester (OEt)
• Ester (OMe)
• Glu (EDANS)
• NHMe
• NHEt
• Tyr (3-NO2)
• MZ3
• OBzl
• OtBu
• ol
• FMK

C-Terminal Modification - Conjugation

• KLH conjugation on C-terminal (-COOH)
• BSA conjugation on C-terminal (-COOH)
• OVA conjugation on C-terminal (-COOH)

C-Terminal Modification - Fluorescence/Dye Labeling

• Biotin (Lys side chain)
• FITC (Lys side chain)
• 5-FAM (Lys side chain)
• TAMRA (Lys side chain)
• DNP (Lys side chain)
• Lys(Dansyl)
• Lys(MCA)

C-Terminal Modification - MAPS and Carrier Complex

• MAPS Asymmetric 2 branches
• MAPS Asymmetric 4 branches
• MAPS Asynmmetric 8 branches

Other Modification

Other Modification - Atom Linker

• {Ahx}, 6 atoms
• {Ava}, 5 atoms
• {8-Aoc}
• {AEA}
• {Ado}
• {ANP Linker}

Other Modification - Conjugation

• KLH conjugation on Cys
• BSA conjugation on Cys
• OVA conjugation on Cys

Other Modification - Cyclic peptide

• Mono disulfide bridge
• Amide cyclic (Head to tail)
• Amide cyclic (Side chain)
• Double disulfide bridge
• Triple disulfide bridge
• Random disulfide bridge
• {Same Seq. Inter-disulfide bridge}
• {Different Seq. Inter-disulfide bridge}
• Cyclic bridge through CH2 moiety and SH of Cys

Other Modification - D form amino acids

• {D-Ala}
• {D-Arg}
• {D-Asp}
• {D-Asn}
• {D-Cys}
• {D-Glu}
• {D-Gln}
• {D-His}
• {D-Allo-Ile}
• {D-Leu}
• {D-Lys}
• {D-Met}
• {D-Pro}
• {D-Phe}
• {D-Ser}
• {D-Tyr}
• {D-Thr}
• {D-Trp}
• {D-Val}

Other Modification - Fluorescence/Dye Labeling

• Lys(Biotin) (middle)
• d-Lys(Biotin) (middle)
• FITC 6
• Lys(FITC) (middle)
• 5,6-FAM
• Lys(5-FAM) (middle)
• Lys(5,6-FAM)
• Lys(Dansyl) (middle)
• Lys(myr)
• 5(6)-TAMTA-
• Lys(TAMRA) (middle)
• 5-TAMRA-Acp
• D-Lys(Dnp) (middle or C-Terminal)
• Dab(Dnp) (middle or C-Terminal), 3-[2,4-dinitrophenyl]-L-2,4-diaminobutyic acid
• Dap(Dnp) (middle or C-Terminal), Dpa, 3-[2,4-dinitrophenyl]-L-2,3-diaminopropionyl
• Lys(MCA) (middle)
• Lys(Rhodamine B)

Other Modification - Glycoslated peptide

• Glycosylation

Other Modification - Homo amino acids

• {Har}
• {D-Har}
• {HomoCit}
• {D-HomoCit}
• {HomoLeu}
• {HomoPro}
• {D-HomoPro}
• {beta-HomoIle}
• {beta-HomoLeu}
• {beta-HomoMet}
• homotyr
• {beta-HomoPro}
• {beta-HomoVal}

Other Modification - Isotope Labeling

• H2 (deuterium)
• N15
• 13C15N-K
• 13C15N-R
• 13C15N-A
• 13C15N-I
• 13C15N-L
• 13C15N-F
• 13C15N-V
• 13C15N-G
• 13C15N-S
• 15N-V

Other Modification - MAPS and Carrier Complex

• Lys(Maleimide)
• Lys(Mpa)
• Lys(Pra)
• Lys(Suc)
• Lys(glutaryl)
• Lys(pGlu)
• Lys(For)
• Lys(2-Br-Ac)
• Lys(Butanoyl)
• Lys(Crotonyl)
• Lys(octenyl)
• lys(Ma)
• Lys(Pal)
• Lys(Oleic Acid)
• Lys(Acryl)
• Lys(alkine)
• Lys(Alloc)
• Lys(Aoa)
• Lys(cyclopropanecarboxyl)
• {Lys(3,5-diiodo-4-hydroxybenzoyl)}
• Lys(Methacryl)
• Lys(propargyl)
• Lys(propionyl)
• Lys(Pyruvoyl)

Other Modification - Methyl amino acids

• {Lys(Me)}
• {Lys(Me2)}
• {Lys(Me3)}

Other Modification - N-Methyl amino acids

• {N-Me-Ala}
• {N-Me-Phe}
• {N-Me-Leu}
• {N-Me-Ile}
• {N-Me-Val}
• {N-Me-Met}
• {N-Me-Nle}
• {N-Me-Nva}
• {N-Me-Gly}, Sar
• {N-Me-Ser}
• {N-Me-Tyr}
• {N-Me-Thr}
• {N-Me-Asp}
• {N-Me-Glu}
• N-Me-beta-Ala

Other Modification - PEG

• {Mini-PEG}, 9 atoms
• {Mini-PEG2}, 13 atoms
• {PEG4}, 16 atoms
• {PEG6}
• {PEG8}
• {PEG11}
• {PEG12}

Other Modification - Phe/Tyr Analogs amino acids

• {D-2-Cl-Phe}
• {L-2-Cl-Phe}
• {D-3-Cl-Phe}
• {L-3-Cl-Phe}
• {D-4-Cl-Phe}
• {L-4-Cl-Phe}
• {D-3,4-DiCl-Phe}
• {L-3,4-DiCl-Phe}
• {D-4-Br-Phe}
• {L-4-Br-Phe}
• {D-3-F-Phe}
• {L-3-F-Phe}
• {D-4-F-Phe}
• {L-4-F-Phe}
• {D-4-NO2-Phe}
• {L-4-NO2-Phe}
• {D-4-I-Phe}
• {L-4-I-Phe}
• {D-3-CN-Phe}
• {L-3-CN-Phe}
• {D-4-CN-Phe}
• {L-4-CN-Phe}
• {D-2-Me-Phe}
• {L-2-Me-Phe}
• {D-4-Me-Phe}
• {L-4-Me-Phe}
• {D-4-NH2-Phe}
• {L-4-NH2-Phe}
• {D-3-Cl-Tyr}
• {L-3-Cl-Tyr}
• {D-3,5-DiCl-Tyr}
• {L-3,5-DiCl-Tyr}
• {D-3,5-DiBr-Tyr}
• {L-3,5-DiBr-Tyr}
• {D-3-I-Tyr}
• {L-3-I-Tyr}
• {D-3,5-DiI-Tyr}
• {L-3,5-DiI-Tyr}
• {D-3-NO2-Tyr}
• {L-3-NO2-Tyr}
• {D-3,5-DiNO2-Tyr}
• {L-3,5-DiNO2-Tyr}
• {L-3-F-Tyr}

Other Modification - Phosphorylation

• Phosphorylation (pSer)
• Phosphorylation (pTyr)
• Phosphorylation (pThr)
• {D-pSer}
• {D-pTyr}
• {D-pThr}
• {Di-sites in sequence}
• {Tri-sites in sequence}

Other Modification - Quenched fluorescent peptide

• DABCYL
• Glu (EDANS)
• Abz
• Tyr (3-NO2)

Other Modification - Quenched fluorescent peptides

• {Lys(DABCYL)}
• {Lys(Abz)}

Other Modification - Stapled peptide

• Stapled peptide (S5-S5)
• Stapled peptide (S5-R8)
• Stapled peptide (R8-R8)

Other Modification - Unusual amino acid

• {Lys(Ac)}
• {Gamma-Glu}
• {Hyp}
• {Cit}

Other Modification - Unusual amino acids

• {Beta-Asp}
• {D-Beta-Asp}
• {D-Gamma-Glu}
• Cys(Cam)
• D-Cys(Cam)
• Cys(Pam)2
• {Cys(Acm)}
• {Cys(tBu)}
• {Met(O)}
• {D-Met(O)}