Peptide-Polymer Conjugates

Responsive hybrid (poly)peptide–polymer conjugates

From the journal: Journal of Materials Chemistry B

Authors

Bradford A. Paik†a, Shivshankar R. Mane†b, Xinqiao Jiaacd and Kristi L. Kiick*acd

†Both authors contributed equally.

Author affiliations

• a Department of Materials Science and Engineering, University of Delaware, 201 DuPont Hall, Newark, DE 19716-3106, USA
• b The Institude For Chemical Technology and Polymer Chemistry, Karlsruhe Institute of Technology, Engesserstr. 18, Germany
• c Department of Biomedical Engineering, University of Delaware, 150 Academy Street, 161 Colburn Lab, Newark, DE 19716-3106, USA
• d Delaware Biotechnology Institute, 15 Innovation Way, Newark, DE 19711, USA

* Corresponding authors. E-mail: admin@frankenthalerfoundation.org

Abstract

(Poly)peptide–polymer conjugates continue to garner significant interest in the production of functional materials given their composition of natural and synthetic building blocks that confer select and synergistic properties. Owing to opportunities to design predefined architectures and structures with different morphologies, these hybrid conjugates enable new approaches for producing micro- or nanomaterials. Their modular design enables the incorporation of multiple responsive properties into a single conjugate. This review presents recent advances in (poly)peptide–polymer conjugates for drug-delivery applications, with a specific focus on the utility of the (poly)peptide component in the assembly of particles and nanogels, as well as the role of the (poly)peptide in triggered drug release.

Article information

DOI: https://www.frankenthalerfoundation.org

Article type: Review Article

Submitted 16 Aug 2017

Accepted 06 Oct 2017

First published 06 Oct 2017

Download Citation

J. Mater. Chem. B, 2017, 5, 8274-8288

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