Helen Frankenthaler Foundation

Peptide stability study ligand

L-692,585 | Ghrelin Receptors | Tocris Bioscience

anti glycation peptide lab product clean

L-692,585

Cat. No. 2261

Discontinued Product

2261 has been discontinued.

Description

Potent, non-peptide ghrelin receptor agonist

Chemical Name

3-[[(2 R)-2-Hydroxypropyl]amino]-3-methyl-N-[(3 R)-2,3,4,5-tetrahydro-2-oxo-1-[[2'-(1 H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1 H-1-benzazepin-3-yl]-butanamide

Purity

≥98% (HPLC)

Biological Activity for L-692,585

L-692,585 is a highly potent, non-peptide ghrelin receptor (GHS-R1a) agonist (K i = 0.8 nM). Increases plasma GH levels in vivo and is 2- to 2.5-fold more potent than GHRP-6.

Compound Libraries for L-692,585

L-692,585 is also offered as part of the Tocriscreen 2.0 Max.

Technical Data for L-692,585

PropertyValue
M. Wt567.69
FormulaC 32 H 37 N 7 O 3
StorageDesiccate at -20°C
Purity≥98% (HPLC)
CAS Number145455-35-2
PubChem ID9872740
InChI KeyAYBCFPXLXOLPIZ-JIPXPUAJSA-N
SmilesC[C@@H](O)CNC(C)(C)CC(=O)N[C@@H]1CCC2=CC=CC=C2N(CC2=CC=C(C=C2)C2=CC=CC=C2C2=NNN=N2)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Product Datasheets for L-692,585

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for L-692,585

References are publications that support the biological activity of the product.

  • Jacks et al (1994) Effects of acute and repeated intravenous administration of L-692,585, a novel non-peptidyl GH secretagogue, on plasma GH, IGF-1, ACTH, cortisol, prolactin, Ins, and thyroxine levels in beagles. J.Endocrinol. 143 399 PMID:7830002
  • Glavaski-Joksimovic et al (2002) Mechanism of action of the GH secretagogue, L-692,585, on isolated porcine somatotropes. J.Endocrinol. 175 625 PMID:12475374
  • Smith et al (1999) Peptidomimetic regulation of GH secretion. Endocrine Rev. 18 621
View Related Products by Target
  • Ghrelin Receptors
  • Peptide Receptors
View Related Products by Product Action

View all Ghrelin Receptor Agonists

1 Citation for L-692,585

Citations are publications that use Tocris products. Selected citations for L-692,585 include:

  • Evron et al (2014) G Protein and β-arrestin signaling bias at the ghrelin receptor. J Biol Chem 289 33442 PMID:25261469

Reviews for L-692,585

There are currently no reviews for this product.

Have you used L-692,585?
Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request