Peptide structure-activity relationship tool

Peptidomimetics via modifications of amino acids and peptide bonds

Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure–activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.

Article Information

DOI: https://www.frankenthalerfoundation.org

Article type: Review Article

Submitted 28 Oct 2013

First published 13 Mar 2014

Authors

Ilker Avan, C. Dennis Hall and Alan R. Katritzky

Author Affiliations

• Department of Chemistry, Faculty of Science, Anadolu University, Eskişehir, Turkey
• Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200, USA

Citation

Chem. Soc. Rev., 2014, 43, 3575-3594