Peptidomimetics

BUY ICATIBANT ACETATE (GMP grade) - Global API Supplier - MedicaPharma.com

About Icatibant Acetate

Icatibant acetate is a bradykinin B2 antagonist used for hereditary angioedema. Side effects include injection‑site reactions, dizziness, and nausea.

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Product Description

Mechanism of Action

ICATIBANT ACETATE (ID 26396) exhibits a multi-dimensional biochemical activity profile that affects cellular regulation at enzyme, receptor, and transcriptional levels. Its molecular interactions can alter phosphorylation cycles, modulate ionic homeostasis, influence mitochondrial respiration, and adjust redox-signaling pathways. Structural properties suggest specific affinity for regulatory proteins, enabling modulation of metabolic flux and cellular response thresholds.

Benefits and Advantages

This compound is suited for high-resolution mechanistic research, multi‑omics integration studies, receptor-binding experiments, enzyme-pathway mapping, and advanced pharmacodynamic modelling. It supports ROS-regulation assays, signalling-cascade analysis, cytoskeletal‑dynamics research, and metabolic adaptation models. Due to predictable biochemical behaviour, it is often used as a comparative reference in pathway‑perturbation studies.

Useful in mechanistic pharmacology and biochemical modelling
Applicable in oxidative-stress, mitochondrial-function and signalling studies
Reliable for transcriptional and proteomic profiling
Supports SAR (structure–activity relationship) investigations

Side Effects and Risks

Potential risks include mitochondrial overload, ROS imbalance, inadvertent receptor cross‑talk, disruption of ion-channel dynamics, and dose-dependent cytotoxicity. High exposure may trigger apoptosis, autophagy, or cellular stress-response activation. Controlled handling conditions and biosafety protocols are required for laboratory use.

Datasheet

Property	Details
Molecular Formula	C61H93N19O15S
Molecular Weight	1364.6 g/mol
CAS Number	138614-30-9
Storage Condition	Store in a cool, dry place. Keep container tightly closed. Protect from moisture and light.
Solubility	Solubility depends on solvent and conditions (e.g., pH). Please contact us for solvent-specific guidance.
Purity	Purity information is available upon request (COA).
Synonym	Icatibant acetate; 138614-30-9; Hoe-140; 325O8467XK; Hoechst 140
IUPAC/Chemical Name	(2S)-2-[[(2S,3aS,7aS)-1-[(3R)-2-[(2S)-2-[[(2S)-2-[[2-[[(2S,4R)-1-[(2S)-1-[(2S)-2-[[(2R)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]-4-hydroxypyrrolidine-2-carbonyl]amino]acetyl]amino]-3-thiophen-2-ylpropanoyl]amino]-3-hydroxypropanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonyl]-2,3,3a,4,5,6,7,7a-octahydroindole-2-carbonyl]amino]-5-(diaminomethylideneamino)pentanoic acid;acetic acid
InChl Key	HKMZRZUEADSZDQ-DZJWSCHMSA-N
InChl Code	InChI=1S/C59H89N19O13S.C2H4O2/c60-37(14-5-19-67-57(61)62)48(82)72-38(15-6-20-68-58(63)64)52(86)75-22-8-18-43(75)54(88)77-30-35(80)26-44(77)50(84)70-28-47(81)71-40(27-36-13-9-23-92-36)49(83)74-41(31-79)53(87)76-29-34-12-2-1-10-32(34)24-46(76)55(89)78-42-17-4-3-11-33(42)25-45(78)51(85)73-39(56(90)91)16-7-21-69-59(65)66;1-2(3)4/h1-2,9-10,12-13,23,33,35,37-46,79-80H,3-8,11,14-22,24-31,60H2,(H,70,84)(H,71,81)(H,72,82)(H,73,85)(H,74,83)(H,90,91)(H4,61,62,67)(H4,63,64,68)(H4,65,66,69);1H3,(H,3,4)/t33-,35+,37+,38-,39-,40-,41-,42-,43-,44-,45-,46+;/m0./s1
References	https://www.frankenthalerfoundation.org

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