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(10-1256-01)
Kit format: 1 x 96 wells
Measurement range: 20-1200 pmol/L
No cross reactivity to human proinsulin or insulin
No cross reactivity to C-peptide in human, macaque, rat or mouse
High specificity - enables specific measurement of porcine C-peptide in xenotransplantation studies
The Porcine C-peptide ELISA is an assay for the quantitative determination of porcine C-peptide in serum, plasma and cell culture medium.
The Porcine C-peptide ELISA may be used for post-transplant assessment of porcine islet xenograft function in human, macaque, rat or mouse. Enables distinguishing endogenously produced C-peptide for pharmacodynamic and/or pharmacokinetic studies during exogenous insulin administration
Species
Porcine
Sample types
Serum, plasma and cell culture medium
Sample volume
10 µL
Assay range
20-1200 pmol/L
Detection limit
≤10 pmol/L
Incubation
2 h + 1 h + 15 min
Detection method
Absorbance
The following cross-reactions have been tested:
Porcine insulin
<0.05 %
Porcine proinsulin
<0.02 %
Human C-peptide
<0.003 %
Human insulin
<0.002 %
Human proinsulin
<0.01 %
Macaque C-peptide
<0.006 %
Mouse insulin
<0.13 %
Mouse proinsulin
Rat C-peptide
0.08 %
Rat insulin
Rat proinsulin
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Download your Safety Data Sheets
Manell, E. A. K., Rydén, A., Hedenqvist, P., Jacobson, M., & Jensen-Waern, M. (2014). Insulin treatment of streptozotocin-induced diabetes re-establishes the patterns in carbohydrate, fat and amino acid metabolisms in growing pigs. Laboratory Animals, 48(3), 261–269. Read more >
Ludwig, B. et al. (2017). Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proceedings of the National Academy of Sciences of the United States of America, 114(44), 11745–11750. Read more >
Lee, S. et al. (2019) Enhanced insulin production and reprogramming efficiency of mesenchymal stem cells derived from porcine pancreas using suitable induction medium. Xenotransplantation, 26(1) p. e12451.' Read more >
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