Streamline your antibody-drug conjugate discovery workflows with our next-gen internalization and degradation assays
When antibodies bind to cell-surface receptors, they trigger endocytosis, internalizing the receptors and antibodies into the cell. This process is vital in research of targeted drug delivery to cancer cells, especially with antibody-drug conjugates (ADCs). ADCs are engineered antibodies linked to potent cytotoxic molecules, which can be trafficked to the lysosome for drug release and tumor cell death or recycled through the endosomal pathway.
Understanding the intracellular trafficking pathways is crucial for advancing drug discovery. ADCs or antibodies can be linked to our pH-sensitive pHrodo dyes to monitor internalization or to our LysoLight dyes to confirm lysosomal degradation, offering easy-to-use tools for effective drug discovery.
Explore pHrodo dye– or LysoLight dye–based assay offerings:
