Proteintech offers a wide range of markers and related antibodies for cardiovascular research
The cardiovascular system is a general term for the heart and blood vessels. Coronary heart disease, cerebrovascular disease, peripheral arterial disease, rheumatic heart disease, congenital heart disease, or deep vein thrombosis and pulmonary embolism are only a few examples of cardiovascular diseases (CVDs). Since CVDs remain a consistently increasing cause of death worldwide, scientists are prioritizing the identification and understanding of the mechanisms of cellular and molecular basics related to CVDs. In 2012, WHO highlighted that more than 30% of our population die because of CVDs (with the majority due to coronary heart disease and stroke).
Age-associated changes in cardiovascular system are leading to deregulation of molecular pathways and pathological alterations (e.g., hypertrophy, altered left ventricular (LV) diastolic function, abnormalities in arterial stiffness or impaired endothelial function). That reflects in significant increase of CVD including atherosclerosis, hypertension or stroke. Inhibition of the mammalian target of rapamycin (mTOR) presents an evidence for being cardioprotective during aging and cardiac stress.
Catalog number: 20657-1-AP Type: Rabbit Polyclonal Publications: 15 Applications: ELISA, IF, IHC, IP, WB
mTOR (Mammalian or Mechanistic Target of Rapamycin) is an atypical serine/threonine kinase that exerts its main cellular functions interacting with specific protein adaptors to form two different complexes: mTORC1 and mTORC2.
The mTOR pathway is a key player in the cardiovascular regulation system. It appears crucial for the maintenance of cardiac structure and function in the postnatal period, adulthood, and also in the development of cardiac hypertrophy. mTOR is also deeply involved in the regulation of cardiac metabolism.
Moreover, the mTOR pathway that partners with Wnt and growth factor signaling are vital for endothelial and cardiomyocyte growth. From the other side, chronic mTOR activation appears to enhance the cardiac aging process.
IF analysis of HeLa cells labeling mTOR with 20657-1-AP Proteintech antibody at a dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IgG(H+L)
IHC analysis of paraffin-embedded human testis tissue slide using 20657-1-AP (mTOR antibody) at dilution of 1:200 (under 10x lens) heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
Catalog number: 15513-1-AP Type: Rabbit Polyclonal Publications: 4 Applications: ELISA, IHC, WB
The troponin complex regulates the contraction of striated muscles and consists of three subunits (troponin C, troponin T, and troponin I). Cardiac troponin T (cTnT) is a 37 kDa protein that binds to tropomyosin, thereby attaching the troponin complex to the thin filament. cTnT is a cardiac regulatory protein that controls the calcium-mediated interaction between actin and myosin.
Defects in cTnT are the cause of cardiomyopathy familial hypertrophic type 2 (CMH2), cardiomyopathy dilated type 1D (CMD1D) and cardiomyopathy familial restrictive type 3 (RCM3). Statistically significant differences were also described in cTnT levels between newborns with heart defects and healthy individuals.
Catalog number: 11265-1-AP Type: Rabbit Polyclonal Publications: 15 Applications: ELISA, FC, IF, IHC, IP, WB
CD31 (PECAM-1 – platelet endothelial cell adhesion molecule-1) is an Ig gene superfamily member, composed of 6 extracellular Ig folds, with a molecular weight of 130 kDa. It is differentially glycosylated involving N-linked and O-linked glycosylation sites.
CD31 is expressed on all cells within the vascular compartment, on the surface of the endothelium. It plays a role in cell-cell adhesion, being an efficient
